Addition of Clonidine to Epidural Morphine Enhances Postoperative Analgesia After Cesarean Delivery (original) (raw)

1994

Abstract

Background and Objectives The randomized, double-blind, dose-response study was designed to evaluate the effects of the addition of clonidine to epidural morphine on postoperative analgesia and side effects in patients undergoing cesarean delivery. Methods Sixty patients, undergoing cesarean delivery under epidural anesthesia, were randomly divided in three equal groups to receive, at the end of surgery, an epidural analgesic mixture consisting of 10 mL solution containing 2 mg of morphine diluted with 0.125% bupivacaine plus 1:800,000 epinephrine and 0, 75, or 150 μg of clonidine. Duration of analgesia was assessed as the pain-free interval between the end of surgery and patient’s first analgesic request. The analgesic mixture was repeated, on patient’s request, to 36 hours after the operation. Arterial blood pressure, heart rate, respiratory rate, and side effects were noted. The total amount of morphine and clonidine delivered was also noted. Results The addition of clonidine (0,...

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