The YAP/TAZ Signaling Pathway in the Tumor Microenvironment and Carcinogenesis: Current Knowledge and Therapeutic Promises (original) (raw)

The Hippo Pathway and YAP/TAZ-TEAD Protein–Protein Interaction as Targets for Regenerative Medicine and Cancer Treatment

Stefania Ferrari

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Molecular Pathways: YAP and TAZ Take Center Stage in Organ Growth and Tumorigenesis

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The Hippo Pathway Effectors YAP/TAZ-TEAD Oncoproteins as Emerging Therapeutic Targets in the Tumor Microenvironment

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YAP/TAZ at the Roots of Cancer

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A feed forward loop enforces YAP/TAZ signaling during tumorigenesis

Shawn Xiong

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YAP and TAZ in Lung Cancer: Oncogenic Role and Clinical Targeting

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The PDZ-binding motif of Yes-associated protein is required for its co-activation of TEAD-mediated CTGF transcription and oncogenic cell transforming activity

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Hippo inactivation feeds tumor-initiating cells

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Recent Therapeutic Approaches to Modulate the Hippo Pathway in Oncology and Regenerative Medicine

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YAP and TAZ: a signalling hub of the tumour microenvironment

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Prevalence of the Hippo Effectors YAP1/TAZ in Tumors of Soft Tissue and Bone

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The Hippo pathway effector YAP inhibits HIF2 signaling and ccRCC tumor growth

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YAP1 acts as a negative regulator of pro-tumor TAZ expression in esophageal squamous cell carcinoma

Li-Wha Wu

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YAP oncogene overexpression supercharges colon cancer proliferation

Joseph Avruch

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The Hippo pathway in normal development and cancer

Ruggero De Maria

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A YAP/TAZ-Regulated Molecular Signature is Associated with Oral Squamous Cell Carcinoma

Stefano Monti

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The Hippo pathway transcriptional co-activator, YAP, is an ovarian cancer oncogene

Elena Takano, Stephen Fox

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YAP and the Hippo pathway in pediatric cancer

Abdalla Mohamed

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Reply to: “YAP in tumorigenesis: Friend or foe?”

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TAZ promotes cell growth and inhibits Celastrol-induced cell apoptosis

Lechuang Chen

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Assays Used for Discovering Small Molecule Inhibitors of YAP Activity in Cancers

Subhajit Maity

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New Insights into the Roles of Yes-Associated Protein (YAP1) in Colorectal Cancer Development and Progression

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Annals of Colorectal Research, 2019

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The Hippo pathway effector TAZ induces TEAD-dependent liver inflammation and tumors

Trang Phạm

Science signaling, 2018

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Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

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Molecular Pathways: Hippo Signaling, a Critical Tumor Suppressor

Heinz-josef Lenz

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TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway

Xin-hai Pei

Molecular and Cellular Biology, 2008

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Reciprocal Crosstalk Between YAP1/Hippo Pathway and the p53 Family Proteins: Mechanisms and Outcomes in Cancer

Nitin Raj

Frontiers in Cell and Developmental Biology, 2019

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Mutant p53 Protein and the Hippo Transducers YAP and TAZ: A Critical Oncogenic Node in Human Cancers

Maria Ferraiuolo

International journal of molecular sciences, 2017

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YAP/TAZ Signalling in Colorectal Cancer: Lessons from Consensus Molecular Subtypes

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TAZ promotes cell proliferation and EMT and is inhibited by the Hippo pathway

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Hippo in Gastric Cancer: From Signalling to Therapy

Christine Varon

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Hippo Pathway Effector Yap Is an Ovarian Cancer Oncogene

Thomas Wheeler

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