Miscellaneous Ethylenedicysteine Versus Diethylenetriamine Pentaacetic Acid as the Carrier of Technetium Tc 99m in Diuretic Renography for Patients with Upper Urinary Tract Obstruction (original) (raw)
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Urology journal, 2006
L,L-ethylenedicysteine (EC) is a new carrier of technetium Tc 99m (99mTc) with a lower affinity to plasma albumin in comparison with diethylenetriamine pentaacetic acid (DTPA). We compared 99mTc-EC scan with 99mTc-DTPA scan in diuretic renography for patients with obstructive uropathy. Thirty-three patients with upper urinary tract obstruction were randomly selected and underwent diuretic renographies by 99mTc-EC and 99mTc-DTPA. The counts of radioisotope per pixel in the target (the kidney) and background tissues as well as the clearance half-life of these two radiopharmaceuticals were measured and compared. Mean counts of radioisotope per pixel in the target tissue was not different between 99mTc-EC and 99mTc-DTPA scans, but in the background tissue, it was less for 99mTc-EC (P = .003). Target-background ratio was higher for 99mTc-EC scan (3.80 +/- 2.11 versus 2.48 +/- 1.39; P < .001). Renal clearance half-life of radioisotope was shorter for 99mTc-EC scan than 99mTc-DTPA scan ...
1994
The radiopharmaceutical @â€oeTc-mercaptoacetyltrig1ycine (@Tc-MAG3) has been introducedas a substitute for 0111 with similar pharmacokinetics and human renogram patterns (4â€"8). On the other hand, there are significant differences between the biologic behavior of @‘@‘Tc-MAG3 and Off!. The plasma protein binding of @Tc-MAG3 is relatively high. Its plasma clearance in humans is not higher than about 65% of the OIH clearance, and the ac curate renal plasma flow estimation with @Tc-MAG3 is relatively difficult(8â€"13). Recently, a new @â€oeTc-labeled agent, @â€oe@Tc-ethylenedi cysteine (EC) was developed as a substitute for OIH by Verbruggen et al. (14â€"16). Excreted from the kidney by active transport, it is easily labeled with @â€oe@Tc at room temperature (16,17). In humans, @Tc-EC has similar cx traction, excretion and renogram patterns as does @9@'c-MAG3. The radiopharmaceutical @9@c-EC has higher plasma clearance and lower hepatobiliarylocalization than 91@'°'Tc-MAG3, and its plasma binding properties are less than those of Off! (14â€"17). The purpose of this study was to evaluate @â€oeTc-EC in obstructive renal disease with various degrees of renal impairment and to compare this agent with @9'c-MAG3 and OIH. MATERIALSAND METHODS PaUen@ Sixteen patients with obstructive renal disease who had proven orsuspectedhydroureteronephrosis (10womenand6 men),mean age 34.2 yr (range19â€"47 yr), were selectedas the studygroup from the patients who were referred to this department for renal investigations. All of themhadundergoneurographic examina tionspriorto the study,whichdemonstrated hydroureteroneph rosinand/orurolithiasis.Serumcreatininelevelswere in the nor mal range in all patients (0.4â€"1.4 mg/dl). In addition, six normal volunteers(twowomenandfourmen),meanage 27.4yr (range 17â€"41 yr)were studiedas a controlgroup.The study protocol was approved by the Medical Faculty Ethical Committee. Technetium-99m-iebeiedN,N-ethyienedlcysteine(@rc-EC) is anew renal Imaging agent introduced as an alternative for 99mTc-labeied mercaptoacety1hig@ne (@rc-MAG3), w@i similarrenal excretion charecteristics. ToeValUatethe diagnostic
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1994
Technetium-99m-labeled N,N-ethylenedicysteine (99mTc-EC) is a new renal imaging agent introduced as an alternative for 99mTc-labeled mercaptoacetyltriglycine (99mTc-MAG3), with similar renal excretion characteristics. To evaluate the diagnostic characteristics of this agent, a gamma camera study was performed. Sixteen patients with obstructive renal disease and six normal controls were injected with 90 to 110 MBq of 99mTc-EC and 7.4 MBq 131I-labeled orthoiodohippurate (OIH). Serial images were obtained during 20 min for 99mTc-EC and 30 min for OIH. The study was repeated using 90 to 110 MBq 99mTc-MAG3 during the same week. Renograms, functional ratios and urinary excretion patterns of all three agents were similar. The mean time to peak activity values for OIH, 99mTc-EC and 99mTc-MAG3 were 4.25 +/- 0.37 min, 4.39 +/- 0.32 min and 4.00 +/- 0.24 min, respectively. The time from peak to 50% activity values for OIH, 99mTc-EC and 99mTc-MAG3 were 5.48 +/- 0.80 min, 6.93 +/- 0.69 min and 7...
The Journal of nuclear …, 1995
necysteine dimer (ECD), and, unlike @Tc-mercap toacetyltriglycine (@Tc-MAG3), it can be easily prepared at room temperature. Animal biodistribution studies have demonstrated that @Tc-EC shows low kidney retention and low liver uptake with rapid urinaryexcretion through the primaryroute of active tubularsecretion (1). In human volunteers, renal clearance of @Tc-EC was significantly higher than that of @‘Tc-MAG3 and it was 75% of or thoiodohippurate (0111) clearance (2). The renogram curves obtained with @9'c-EC were superior to @9@c-
Değerlendirme technetium-99m-ethylenedicysteine, renal bozukluklar ve tayini (ekstraksiyon oranı
The Journal of nuclear …, 1995
necysteine dimer (ECD), and, unlike @Tc-mercap toacetyltriglycine (@Tc-MAG3), it can be easily prepared at room temperature. Animal biodistribution studies have demonstrated that @Tc-EC shows low kidney retention and low liver uptake with rapid urinaryexcretion through the primaryroute of active tubularsecretion (1). In human volunteers, renal clearance of @Tc-EC was significantly higher than that of @‘Tc-MAG3 and it was 75% of or thoiodohippurate (0111) clearance (2). The renogram curves obtained with @9'c-EC were superior to @9@c-
European Journal of Nuclear Medicine, 1991
Simultaneous measurements of the clearance rates of technetium 99m diethylenetriaminepentaacetie acid (99mTc-DTPA) and chronium 51 ethylenediaminetetraaeetic acid (SICr-EDTA) were performed in 30 patients with a range of renal function (glomerular filtration rates between 9 and 120 ml/min). Using multiple blood samples, the two clearance values correlated well (r=0.991, standard error 3.9 ml/min), but DTPA clearance was systematically higher by 7.6%. For each radiopharmaceutical, an equation was derived to correct clearance values obtained using only plasma samples taken at 2 and 4 h for the systematic error inherent in this technique compared with analysis of the complete plasma concentration-time curve. The root mean square error remaining after application of these equations was 1.9 ml/min for both the EDTA and DTPA data. The corresponding errors obtained using the equation derived by Brochner-Mortensen for EDTA plasma clearance were 2.2 ml/min and 1.9 ml/min, respectively, these values were not significantly different from those obtained using the equations derived in this study. Key words: Glomerular filtration rate -Technetium 99m diethylenetriaminepentaacetic acid -Chromium 51 ethylenediaminetetraaeetic acid Eur J Nucl Med (1991) 18:391-395
Sao Paulo Medical Journal, 2008
CONTEXT AND OBJECTIVE: Studies using radionuclides are the most appropriate method for estimating renal function. Dimercaptosuccinic acid chelate labeled with technetium-99m (99mTc-DMSA) is the radiopharmaceutical of choice for high-resolution imaging of the renal cortex and estimation of the functional renal mass. The aim of this study was to evaluate a simplified method for determining the absolute renal uptake (ARU) of 99mTc-DMSA prior to nephrectomy, using the radioactivity counts of nephrectomy specimens as the gold standard. DESIGN AND SETTING: Prospective study at the Division of Nuclear Medicine, Department of Radiology, Universidade Estadual de Campinas. METHODS: Seventeen patients (12 females; range 22-82 years old; mean age 50.8 years old) underwent nephrectomy for various reasons. Renal scintigraphy was performed three to four hours after intravenous administration of a mean dose of 188.7 MBq (5.1 mCi) of 99mTc-DMSA, which was done six to 24 hours before surgery. The in ...
European Journal of Nuclear Medicine and Molecular Imaging, 2002
It has been suggested that determination of differential renal function (DRF)using technetium-99m dimercaptosuccinic acid (DMSA) may lead to overestimation of the function of an obstructed kidney in patients with excretion abnormalities owing to pelvic retention of DMSA. Recently published guidelines have recommended use of furosemide injection when calculating DRF in these particular patients. The aim of this study was to evaluate the effect of diuretic administration on the determination of DRF using DMSA scintigraphy. For this purpose, 19 patients, aged from 1 month to 69 years (19.4±24.8 years, 15 males, 4 females), in whom pelvic retention had been documented by diuresis scintigraphy were included in the study. DMSA scintigraphy was performed in all patients 2-4 h after injection and six planar images were obtained. Immediately after the standard study, furosemide was injected in all patients, and 30 min later the same number of images was obtained. DRF was calculated for each patient and from each DMSA study by using the arithmetic mean method. The difference between two studies (DMSA scintigraphy with or without furosemide administration and diuresis scintigraphy) was expressed as a percentage of the mean value of the two studies (the DRF value of the affected kidney was thus taken into account). The mean of the differences represented the systemic bias and the SD of the mean of the differences represented the precision of the technique. In seven patients, diuresis renography revealed an obstructive curve pattern. We did not observe any significant difference between the DRF values obtained before and after diuretic administration (P>0.5). When we compared DRF values obtained from standard and from diuretic DMSA studies, the mean of the differ-ences was only 0.3% and the SD was only 1.2%. There was also no significant difference in DRF between patients with the obstructive curve pattern and those with a dilated renogram curve pattern (with washout of activity during the second phase of the study) (P>0.1). In conclusion, we did not observe interference from pelvicalyceal activity in patients with documented pelvic retention and infer that diuretic administration may be a useless intervention for improving the accuracy of determination of DRF.