Prognosis of Breast Cancer in Very Young Age (Less Than 30 Years) (original) (raw)
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Breast cancer in women under the age of 35: About 21 cases
International Journal of Clinical Obstetrics and Gynaecology, 2020
Background: Breast cancer is a serious disease. Its incidence in young women is constantly increasing. The objective of the study is to analyze the epidemiological, clinical, therapeutic and prognostic characteristics of breast cancer in young women under 35 years-old. Method: This is a retrospective study about 21 cases of patients aged less than 35 years treated in the gynecology and obstetrics department of the university hospital Mohammed VI of Oujda, Morocco between January 2015 and December 2018. Results: The frequency of breast cancer in young women under 35 was 12.7% in our center. The age average was 31.5 years. 38% had a family history of cancer and among them, 28% had a family history of breast cancer, 5% of endometrial cancer and 5% of colon cancer. The self-examination of a nodule was predominant (57.1%). T3 tumors were the most common (43%), followed by T4 tumors (33%). 24% were immediately metastatic with predominantly pulmonary locations (48%). It was invasive carcinoma of nospecial type in 43% of cases, with predominance of SBR grade II and III (84%). Hormone receptors were positive in 57% of cases and no overexpression of HER2 was found. 18 patients underwent surgery, radical in 61% of cases. 18 had a locoregional irradiation, 58.8% received adjuvant chemotherapy. Hormonal therapy was prescribed in 66.6% of cases. After an average follow-up of 14.7 months, 40% presented relapses. The overall 3-years survival was 38% and the relapse-free survival 40%. Conclusion: Our series joins the data of the literature pleading in favor of the more advanced forms and the more unfavorable prognosis of breast cancer in young patients.
2019
Introduction: Breast cancer is one of the most common malignancies among women in most developed and developing regions of the world. In India, breast cancer is the second most common cancer (after cervical cancer). Breast cancer at young age has been reported to have a more aggressive behavior and unfavorable prognosis compared to the older patients. Aims and Objectives: To evaluate prognosis through pathological tumour size, histological grade, mitotic index, lymph node status, distant metastasis and oestrogen & progesterone receptor positivity in young patients ≤ 35 years. Material and Methods: This prospective study was carried out for a period of three years from June 2015 to May 2018. Total of 200 cases of breast carcinoma were studied, out of them patients with ≤35 years were considered as case group and above 35 years of age as control group. Results: Total of 200 cases of breast carcinoma was reported in various age groups in histopathology. Total cases in age group ≤35 years were 28 out of total 200 cases. In age group ≤35 years out of 28 cases, 09 cases showed positive family history, 22 cases showed lymph node metastasis, most common stage of breast carcinoma was stage III, most common histological grade was Grade III and 15 cases were negative for markers ER/PR. Conclusion: Breast cancer is uncommon in young women but it co-relates with a less favorable prognosis. Tumors in younger patients had higher co-morbidity and better screening procedures should be used even in females younger than 35 years of age.
Breast Cancer in Young Women: Poor Survival Despite Intensive Treatment
PLoS ONE, 2009
Background: Breast cancer is uncommon in young women and correlates with a less favourable prognosis; still it is the most frequent cancer in women under 40, accounting for 30-40% of all incident female cancer. The aim of this study was to study prognosis in young women, quantifying how much stage at diagnosis and management on the one hand, and tumour biology on the other; each contribute to the worse prognosis seen in this age group.
Clinical Characteristics of Breast Cancer in Young Women ≤40 Years Old, Minia, Egypt
Minia Journal of Medical Research, 2020
Background: Breast cancer (BC) was the most common cancer in women worldwide, contributing 25.4% of the total number of new cases diagnosed in 2018, and approximately 7% of women with BC are diagnosed before the age of 40 years the BC in young females differ, so It need more attention. Aim: To describe some clinical characteristics of BC in young females patient's ≤40 years old attending Minia oncology center. Research hypothesis: clinical characteristics of BC may differ in young females. Subjects and methods: This a cross sectional study was conducted included 100 women ≤ 40 years old attending Minia oncology center with BC. Subjects participating in the study filled in a questionnaire including questions about socio-demographic data, and medical data concerning BC. Results: the females enrolled in study 100 BC females ≤ 40 years old, and Mean age of the studied cases was 33.5±3.8. The commonest complaint was lump, the most common stages was stage III and stage IV. With slightly high rate of metastasis and recurrence rate. About half is ER and PR positive and about 29% was triple negative. In females' ≤40 years had a progressive manner as the most common stages was stage III(37%)and stage IV (34%). About 13% had experience of recurrence, and metastasis was seen in 21% of studied females. Recommendation; There is a need to increase awareness about BC among younger women as this age group under presented , its serious consequences' and as well as establishment screening tools and programs is important to focus on BC in young women.
EP026/#1090 Breast cancer in young women
E-Posters
, were enrolled in this retrospective study. Clinicopathological data on pathological tumor size, the status of pathological lymph node metastasis, and clinical course were extracted from patients' medical records. Histological slides were reviewed for variables including tumor morphology and hormonal status. Additional clinical data were obtained from electronic medical records. The Kaplan-Meier method was used to determine the association between survival and TILS. Results Our series contained 123 cases of invasive ductal carcinomas. The mean age was 52 years with extremities of 26 and 102 years. TILS were not significantly associated to response to neoadjuvant chemotherapy (p= 0,728), to metastases (p= 0,737), neither to recurrences (p=0,939). Furthermore, TILs were not associated with the overall survival (p=0,928). Conclusions In this series, TILs seem not to be associated with outcomes. We did not find additional benefits for estimating TILs in triple-positive breast cancer.
JCO global oncology, 2020
PURPOSE Multiple studies have reported that breast cancer in young patients is associated with aggressive characteristics, and it is suggested that prognosis is worse independently of pathologic variables. PATIENTS AND METHODS We performed a retrospective analysis of the Breast Cancer Registry of the Argentinian Society of Mastology, including public and private centers. Patients ≤ 40 years of age at diagnosis were classified as "young," and patients ≤ 35 years of age at diagnosis were classified as "very young." Univariate and multivariate analyses were performed to detect differences between groups. RESULTS Patients ≤ 40 years of age comprised 10.40% (739/7,105) of the participants, with an average age of 35.61 6 4.04 years. Multivariate analysis showed that human epidermal growth factor receptor 2 (HER2)positive tumor phenotype (odds ratio [OR], 1.82), nodal involvement (OR, 1.69), histologic grade (grade 3 OR, 1.41), and tumor size (T2 OR, 1.37; T3-T4, 1.47) were independently associated with younger age at diagnosis. Patients ≤ 35 years of age (n = 286), compared with patients 36 to 40 years of age, had a higher proportion of HER2 tumors (24.58% v 16.94%; P = .021), absence of progesterone receptor expression (29.85% v 22.95%; P = .043), and stage 3 cancer (29.34% v 18.52%; P , .001). Fewer breast-conserving surgeries (75.37% v 62.89%; P , .001) and more adjuvant chemotherapy (59.04% v 36.66%; P , 0.001) were reported in patients ≤ 40 years of age. CONCLUSION In the population studied, breast cancer in young women was associated with aggressive pathologic features and locally advanced disease at the time of diagnosis. Moreover, tumor characteristics in very young patients with breast cancer nested in the population ≤ 40 years of age showed differences in important prognostic factors. More high-quality evidence is needed to improve treatment strategies in these patients.
Breast Cancer under 40 Years of Age: Increasing Number and Worse Prognosis
Pathology & Oncology Research, 2010
Breast cancer at a relatively young age with a poor prognosis is currently exhibiting an increasing incidence. In a retrospective cohort analysis of early breast cancer cases after surgery from our institutional patient registry, 141 patients aged ≤40 years constituted the younger group, with 300 randomly selected patients aged >40 years as controls. A significant and steady increase was found in the relative number of younger cases during the years 2004-2009. The histological type and grade and the lymph node status of the cancers differed significantly between the two groups, with more aggressive biological behaviour, a more advanced stage and a worse prognosis in the younger group. Half of the cancers in the younger cohort were ER-negative, while two-thirds in the control group were ER-positive. Comparatively more tumours were PR-positive and HER2-negative in the control group than in the younger group. The rates of triple-negative cases were 25% and 13% in the younger age and the control group, respectively (p=0.026). Significantly higher mastectomy and axillary block dissection rates were observed in the younger age group, and more chemotherapy was administered than in the control group. Our findings demonstrate the significance of breast cancer in cases aged <40 years, and draw attention to the need for appropriate care in these cases.
Evaluation of the Long-Term Survival in Non-Metastatic Young Breast Cancer Patients in South of Iran
Zanjan University of Medical Sciences, 2022
10.30699/jambs.30.141.333 Background & Objective: The lack of breast cancer screening in young women leads to late disease diagnosis and worse outcomes in this age group. This study was designed to evaluate clinicopathological features and long-term outcomes of young breast cancer women in south of Iran. Materials & Methods: This is a retrospective study of breast cancer patients who were pathologically diagnosed during 2005 to 2017. Data from 284 breast cancer patients aged 40 years or younger were included in this study. Demographic, clinicopathological properties as well as treatment modalities including type of surgery, adjuvant radiotherapy, and adjuvant or neoadjuvant chemotherapy were recorded and analyzed. Results: Median age of the patients was 36 (range 23-40) years. After a median follow-up of 68 months, 21 patients had died due to the disease, 59 patients were alive with the disease, and 204 patients were alive without the disease. The univariate COX regression demonstrated that the disease-free survival (DFS) was significantly low in patients who had undergone breast conservation surgery (BCS) and also patients with higher stages, estrogen/progesterone-negative and human epidermal growth factor receptor 2-positive (ER-/PR-/HER2+) status. Low overall survival (OS) was also significantly associated with stage. According to multivariate COX regression, BCS, stages II, III and also young age were independent predictive factors for low DFS. Conclusion: Given the aggressive features and worse outcome of young breast cancer patients, treatment remains tough and screening seems to be required at young age. Further studies are required to find best management and therapeutic protocols for these patients.