The splice of life: Alternative splicing and neurological disease (original) (raw)

Targeting Splicing in the Treatment of Human Disease

Cristina Hernandez-Munain

Genes, 2017

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Alternative splicing and cell survival: from tissue homeostasis to disease

Maria Paronetto

Cell Death & Differentiation, 2016

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Precise temporal regulation of alternative splicing during neural development

Maurice Swanson

2018

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Discovery of RNA splicing and genes in pieces

Arnold Berk

Proceedings of the National Academy of Sciences of the United States of America, 2016

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Dynamics and Functional Roles of Splicing Factor Autoregulation

Guohao Liang

SSRN Electronic Journal, 2021

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ASD: the Alternative Splicing Database

T. Thanaraj

Nucleic Acids Research, 2004

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A Slow RNA Polymerase II Affects Alternative Splicing In Vivo

Paula Cramer

Molecular Cell, 2003

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Splice-mediated Variants of Proteins (SpliVaP) – data and characterization of changes in signatures among protein isoforms due to alternative splicing

T. Thanaraj

BMC Genomics, 2008

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A coactivator of pre-mRNA splicing

Robbyn Issner

Genes & Development, 1998

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Innovative Therapeutic and Delivery Approaches Using Nanotechnology to Correct Splicing Defects Underlying Disease

Cristina Hernandez-Munain

Frontiers in Genetics, 2020

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Correction of pseudoexon splicing caused by a novel intronic dysferlin mutation

Diane McKenna-Yasek

Annals of Clinical and Translational Neurology, 2019

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Mutations affecting mRNA splicing are the most common molecular defects in patients with neurofibromatosis type 1

Xavier Estivill

Human Molecular Genetics, 2000

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Identification of an RNA Binding Specificity for the Potential Splicing Factor TLS

Marc Hallier

Journal of Biological Chemistry, 2000

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A giant novel gene undergoing extensive alternative splicing is severed by a Cornelia de Lange-associated translocation breakpoint at 3q26.3

John Burn

Human Genetics, 2004

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Disrupted minor intron splicing is prevalent in Mendelian disorders

Philippe Campeau

Molecular Genetics & Genomic Medicine, 2020

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Yeast mRNA splicing in vitro

John Abelson

Journal of Biological Chemistry, 1985

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Specific splicing defects in S. pombe carrying a degron allele of the Survival of Motor Neuron gene

Bryan Neel

The EMBO Journal, 2010

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Functional analysis of splicing mutations and of an exon 2 polymorphic variant ofSERPING1/C1NH

christian drouet

Human Mutation, 2006

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Revealing Global Regulatory Features of Mammalian Alternative Splicing Using a Quantitative Microarray Platform

Christine Misquitta

Molecular Cell, 2004

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Aberrant splicing in neurological diseases

Dairong Feng

Wiley Interdiscip Rev RNA, 2013

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Spliceotherapy: Targeting Spliceosome Assembly to Treat Spliceopathies

Muhammad Ashraf

2012

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Alternative splicing in plants – coming of age

Andrea Barta

Trends in Plant Science, 2012

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Multiple cryptic splice sites can be activated by IDS point mutations generating misspliced transcripts

Mirella Filocamo

Journal of Molecular Medicine, 2006

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Complexities of 5'splice site definition: implications in clinical analyses

NataÅa Skoko

2012

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Somatic Mutations in Core Spliceosome Components Promote Tumorigenesis and Generate an Exploitable Vulnerability in Human Cancer

Maria Paronetto

Cancers, 2022

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ASPicDB: a database of annotated transcript and protein variants generated by alternative splicing

rita casadio

Nucleic Acids Research, 2011

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Quantification of splice variants using real-time PCR

Ludwine Messiaen

Nucleic Acids Research, 2001

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The role of alternative splicing in cancer

Qurat Qureshi

Transcription, 2017

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Genetic regulation of RNA splicing in human pancreatic islets

Ignasi Morán

bioRxiv (Cold Spring Harbor Laboratory), 2021

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AID splice variants lack deaminase activity

Richard Bende

…, 2009

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Interaction of protein phosphatase type 1 with a splicing factor

Ferenc Erdödi

FEBS Letters, 1996

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Unusual splicing events result in distinct Xin isoforms that associate differentially with filamin c and Mena/VASP

Peter F M van der Ven

Experimental Cell Research, 2006

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Elimination of mRNA splicing by a point mutation outside the conserved GU at 5′ splice sites

Arnold Berk

Nucleic Acids Research, 1984

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Alternative splicing and disease

Heike Stier

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2009

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Recurrent bi-allelic splicing variant c.454+3A>G in TRAPPC4 is associated with progressive encephalopathy and muscle involvement

Parneet Kaur

Brain, 2020

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