Cyclization of β-Chlorovinyl Thiohydrazones into Pyridazines: A Mechanistic Study (original) (raw)

Synthesis of thiazol, thiazinan, thiadiazin, thiazolidin, triazine, thioxo-pyrimidin and thioxo-imidazolidine by inter-intra molecular cyclization

2018

Thiazols, triazines, imidazolidines, thiadiazines, thiazolidines and thiones are key structural motif and attracted considerable attention because of their applications in pharmaceutical and biological systems. Many of the scaffolds interestingly exhibits antiproliferative, anti-asthmatic, anti-inflammatory, anti-tubercular, anti-depressant, anti-cancer, antiviral, anti-ulcers, anti-hypertensives, antihistaminics, anti-diabetic, anti-protozoal, neuroprotective, anti-oxidant, and molluscicidal activities. Furthermore, literature explorations revealed that, much work have been reported on inter molecular cyclization reaction of thiourea with phenacyl bromide , chloroacetic acid, chloroacetyl chloride, and α,βunsaturated acid in various reaction condition. Synthesis of aza-heterocycles from N,N’-disubstituted thioureas and 2-phenyl-amino-thiazolines from (2hydroxyethyl)-phenylthioureas have been reported by intra molecular cyclization using TsCl/NaOH. The development of useful organic ...