Experimental strategy for translational studies of organophosphorus pesticide neurotoxicity based on real-world occupational exposures to chlorpyrifos (original) (raw)

Abstract

Translational research is needed to understand and predict the neurotoxic consequences associated with repeated occupational exposures to organophosphorus pesticides (OPs). In this report, we describe a research strategy for identifying biomarkers of OP neurotoxicity, and we characterize pesticide application workers in Egypt's Menoufia Governorate who serve as our anchor human population for developing a parallel animal model with similar exposures and behavioral deficits and for examining the influence of human polymorphisms in cytochrome P450 (CYP) and paraoxonase 1 (PON1) enzymes on OP metabolism and toxicity. This population has previously been shown to have high occupational exposures and to exhibit a broad range of neurobehavioral

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References (45)

  1. Abdel Rasoul GM, Abou Salem ME, Mechael AA, Hendy OM, Rohlman DS, Ismail AA. Effects of occupational pesticide exposure on children applying pesticides. Neurotoxicology. 2008; 29:833-8. [PubMed: 18662718]
  2. Abel T, Nguyen PV, Barad M, Deuel TA, Kandel ER, Bourtchouladze R. Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory. Cell. 1997; 88:615-26. [PubMed: 9054501]
  3. Arcury TA, Grzywacz JG, Talton JW, Chen H, Vallejos QM, Galvan L, et al. Repeated pesticide exposure among North Carolina migrant and seasonal farmworkers. American Journal of Industrial Medicine. 2010; 53:802-13. [PubMed: 20623661]
  4. Barr DB, Allen R, Olsson AO, Bravo R, Caltabiano LM, Montesano A, et al. Concentrations of selective metabolites of organophosphorus pesticides in the United States population. Environmental Research. 2005; 99:314-26. [PubMed: 16307973]
  5. Bushnell, PJ.; Moser, VC. Behavioral toxicity of cholinesterase inhibitors. In: Gupta, RC., editor. Toxicology of Organophosphate and Carbamate Compounds. Elsevier; San Diego, CA: 2006. p. 347-60.
  6. Casida JE, Quistad GB. Serine hydrolase targets of organophosphorus toxicants. Chemico-biological interactions. 2005; 157-158:277-83. [PubMed: 16243304]
  7. Chakraborti TK, Farrar JD, Pope CN. Comparative neurochemical and neurobehavioral effects of repeated chlorpyrifos exposures in young and adult rats. Pharmacology, biochemistry, and behavior. 1993; 46:219-24.
  8. Colosio C, Tiramani M, Brambilla G, Colombi A, Moretto A. Neurobehavioural effects of pesticides with special focus on organophosphorus compounds: which is the real size of the problem? Neurotoxicology. 2009; 30:1155-61. [PubMed: 19751763]
  9. Costa LG. Current issues in organophosphate toxicology. Clin Chim Acta. 2006; 366:1-13. [PubMed: 16337171]
  10. Durham WF, Wolfe HR, Elliott JW. Absorption and excretion of parathion by spraymen. Archives of Environmental Health. 1972; 24:381-7. [PubMed: 5031564]
  11. Dziedzic T. Systemic inflammatory markers and risk of dementia. Am J Alzheimers Dis Other Demen. 2006; 21:258-62. [PubMed: 16948290]
  12. Echbichon, DJ.; Joy, RM. Pesticides and neurological diseases. CRG Press; Boston and London: 1995. Egyptian Ministry of Agriculture. Website of the Egyptian Ministry of Agriculture. 2008.
  13. Ellison CA, Smith JN, Lein PJ, Olson JR. Pharmacokinetics and pharmacodynamics of chlorpyrifos in adult male Long-Evans rats following repeated subcutaneous exposure to chlorpyrifos. Toxicology. 2011; 287:137-44. [PubMed: 21708215]
  14. Ellman GL, Courtney KD, Andres V, Featherstone RM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochemical pharmacology. 1961; 7:88-95. [PubMed: 13726518]
  15. Farahat FM, Ellison CA, Bonner MR, McGarrigle BP, Crane AL, Fenske RA, et al. Biomarkers of chlorpyrifos exposure and effect in Egyptian cotton field workers. Environ Health Perspect. 2011; 119:801-6. [PubMed: 21224175]
  16. Farahat FM, Fenske RA, Olson JR, Galvin K, Bonner MR, Rohlman DS, et al. Chlorpyrifos exposures in Egyptian cotton field workers. Neurotoxicology. 2010; 31:297-304. [PubMed: 20193710]
  17. Farahat TM, Abdelrasoul GM, Amr MM, Shebl MM, Farahat FM, Anger WK. Neurobehavioural effects among workers occupationally exposed to organophosphorous pesticides. Occupational and environmental medicine. 2003; 60:279-86. [PubMed: 12660376]
  18. Foxenberg RJ, Ellison CA, Knaak JB, Ma C, Olson JR. Cytochrome P450-specific human PBPK/PD models for the organophosphorus pesticides: chlorpyrifos and parathion. Toxicology. 2011; 285:57-66. [PubMed: 21514354]
  19. Foxenberg RJ, McGarrigle BP, Knaak JB, Kostyniak PJ, Olson JR. Human hepatic cytochrome p450- specific metabolism of parathion and chlorpyrifos. Drug metabolism and disposition: the biological fate of chemicals. 2007; 35:189-93. [PubMed: 17079358]
  20. Hernandez A, Gomez MA, Pena G, Gil F, Rodrigo L, Villanueva E, et al. Effect of long-term exposure to pesticides on plasma esterases from plastic greenhouse workers. Journal of Toxicology & Environmental Health Part A. 2004; 67:1095-108. [PubMed: 15205026]
  21. Hesham S, Mazen M, El-Damaty M. Quality of training service for agricultural workers in some Egyptian governorates. Egyptian Journal of Agricultural Research. 2006; 84:1646-50.
  22. Hines CJ, Deddens JA. Determinants of chlorpyrifos exposures and urinary 3,5,6-trichloro-2-pyridinol levels among termiticide applicators. The Annals of occupational hygiene. 2001; 45:309-21. [PubMed: 11378153]
  23. Hofmann JN, Keifer MC, Checkoway H, De Roos AJ, Farin FM, Fenske RA, et al. Biomarkers of sensitivity and exposure in washington state pesticide handlers. Adv Exp Med Biol. 2010; 660:19- 27. [PubMed: 20221867]
  24. Issa Y, Sham'a FA, Nijem K, Bjertness E, Kristensen P. Pesticide use and opportunities of exposure among farmers and their families: cross-sectional studies 1998-2006 from Hebron governorate, occupied Palestinian territory. Environmental Health. 2010; 9:63. [PubMed: 20959000]
  25. Jett, DA.; Lein, PJ. Non-cholinesterase mechanisms of central and peripheral neurotoxicity: Muscarinic receptors and other targets. In: Gupta, RC., editor. Toxicology of Organophosphate and Carbamate Compounds. Elsevier; San Diego, CA: 2006a. p. 233-46.
  26. Jett, DA.; Lein, PJ. Non-cholinesterase mechanisms of central and peripheral neurotoxicity: Muscarinic receptors and other targets. In: Gupta, RC., editor. Toxicology of Organophosphate and Carbamate Compounds. Elsevier; San Diego, CA: 2006b. p. 233-46.
  27. Joy S, Fein D, Kaplan E. Decoding digit symbol: speed, memory, and visual scanning. Assessment. 2003; 10:56-65. [PubMed: 12675384]
  28. Kadiiska MB, Gladen BC, Baird DD, Germolec D, Graham LB, Parker CE, et al. Biomarkers of oxidative stress study II: are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning? Free Radic Biol Med. 2005a; 38:698-710. [PubMed: 15721980]
  29. Kadiiska MB, Gladen BC, Baird DD, Graham LB, Parker CE, Ames BN, et al. Biomarkers of oxidative stress study III. Effects of the nonsteroidal anti-inflammatory agents indomethacin and meclofenamic acid on measurements of oxidative products of lipids in CCl4 poisoning. Free Radic Biol Med. 2005b; 38:711-8. [PubMed: 15721981]
  30. Lockridge O, Masson P. Pesticides and susceptible populations: people with butyrylcholinesterase genetic variants may be at risk. Neurotoxicology. 2000; 21:113-26. [PubMed: 10794391]
  31. Lockridge O, Schopfer LM. Review of tyrosine and lysine as new motifs for organophosphate binding to proteins that have no active site serine. Chemico-biological interactions. 2010; 187:344-8. [PubMed: 20211158]
  32. Mostafa, S. Head, Menoufia Pest Control administration; Menoufia Governorate. Shebin El-Kom; Egypt: 2008.
  33. Mrak RE, Griffin WS. Potential inflammatory biomarkers in Alzheimer's disease. J Alzheimers Dis. 2005; 8:369-75. [PubMed: 16556968]
  34. Pancetti F, Olmos C, Dagnino-Subiabre A, Rozas C, Morales B. Noncholinesterase effects induced by organophosphate pesticides and their relationship to cognitive processes: implication for the action of acylpeptide hydrolase. J Toxicol Environ Health B Crit Rev. 2007; 10:623-30. [PubMed: 18049927]
  35. Perez-Herrera N, Polanco-Minaya H, Salazar-Arredondo E, Solis-Heredia MJ, Hernandez-Ochoa I, Rojas-Garcia E, et al. PON1Q192R genetic polymorphism modifies organophosphorous pesticide effects on semen quality and DNA integrity in agricultural workers from southern Mexico. Toxicology and applied pharmacology. 2008; 230:261-8. [PubMed: 18430447]
  36. Pope C, Karanth S, Liu J. Pharmacology and toxicology of cholinesterase inhibitors: uses and misuses of a common mechanism of action. Environmental Toxicology and Pharmacology. 2005; 12:433- 46. [PubMed: 21783509]
  37. Pope CN. Organophosphorus pesticides: do they all have the same mechanism of toxicity? J Toxicol Environ Health B Crit Rev. 1999; 2:161-81. [PubMed: 10230392]
  38. Povey AC, Jury F, Dippnall WM, Smith AE, Thomson S, Mackness B, et al. GST CYP and PON1 polymorphisms in farmers attributing ill health to organophosphate-containing sheep dip. Biomarkers. 2007; 12:188-202. [PubMed: 17536768]
  39. Robbins TW. Shifting and stopping: fronto-striatal substrates, neurochemical modulation and clinical implications. Philosophical transactions of the Royal Society of London Series B, Biological sciences. 2007; 362:917-32.
  40. Rohlman DS, Anger WK, Lein PJ. Correlating neurobehavioral performance with biomarkers of organophosphorous pesticide exposure. Neurotoxicology. 2010
  41. Rohlman DS, Anger WK, Lein PJ. Correlating neurobehavioral performance with biomarkers of organophosphorous pesticide exposure. Neurotoxicology. 2011; 32:268-76. [PubMed: 21182866]
  42. Soltaninejad K, Abdollahi M. Current opinion on the science of organophosphate pesticides and toxic stress: a systematic review. Med Sci Monit. 2009; 15:RA75-90. [PubMed: 19247260]
  43. Usui N, Haji T, Maruyama M, Katsuyama N, Uchida S, Hozawa A, et al. Cortical areas related to performance of WAIS Digit Symbol Test: a functional imaging study. Neuroscience letters. 2009; 463:1-5. [PubMed: 19631255]
  44. Yassin MM, Abu Mourad TA, Safi JM. Knowledge, attitude, practice, and toxicity symptoms associated with pesticide use among farm workers in the Gaza Strip. Occupational and Environmental Medicine. 2002; 59:387-93. [PubMed: 12040114]
  45. Zaim, M.; Jambulingam, P. Global insecticide use for vector-borne disease control. 3rd ed. Diseases DoCoNT. , editor. World Health Organization; Geneva: 2007.