A singleiv dose of ondansetron 8 mg prior to induction of anaesthesia reduces postoperative nausea and vomiting in gynaecological patients (original) (raw)
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Anaesthesia, 1993
The efficacy and safety of ondansetron in preventing postoperative nausea and vomiting.fol1owing major gynaecological surgery was evaluated in this multicentre, double-blind study. A total of 243 patients were randomised to receive three doses of oral ondansetron 8 mg or matching placebo at &hourly intervals, nith the first dose being given an hour before surgery. A standard general anaesthetic technique was employed throughout. Nausea, vomiting and safety assessments were performed continuously during the 24 h postrecovery period. Of the 237 patients evaluated for eficacy, signijicantly fewer ondansetron 8 mg treated patients (6511 17; 56%) experienced postoperative nausea andlor vomiting compared with placebo-treated patients (94/120; 78%) during the stud?. period (p < 0.001). In addition, ondansetron 8 mg reduced the severity of nausea (p < 0.001) and the total number of vomiting episodes experienced (p < 0.001). Overall. ondansetron 8 mg was well tolerated and effective in preventing postoperative nausea and vomiting in this surgical setting.
IP Innovative Publication Pvt. Ltd., 2019
Context: Postoperative Nausea and Vomiting (PONV) is associated with many adverse events, which prolong and increase the healthcare cost. Aims: To compare the efficacy of Palanosetron with respect to Granisetron and Ondansetron in prevention of PONV. To study the need of rescue antiemetic and incidence of side effects. Settings and Design: This Prospective, Randomized study was carried out with 150 adult female patients of ASA Grade I & II posted for elective gynecological surgery under GA. Materials and Methods: Patients were divided into three groups of 50 patients each. Group O received injection ondansetron 8 mg IV, Group G received Granisetron 2.5 mg IV & Group P received Palanosetron 0.075 mg iv before GA induction. Episodes of nausea, vomiting, need for rescue antiemetic and side effects were observed for 72 hours in postoperative period. Statistical Analysis Used: Graphpad Software with consideration of significant P value <0> Results: Incidence of nausea and vomiting was more with Ondansetron and minimal with Palanosetron with statistical significance of P< 0> Lowest incidence of nausea was found with Palanosetron during 3-24 hours postoperatively (P<0> Complete Control of PONV (No PONV, No rescue drug required) was maximum in P group in all hours of study [P<0> Conclusion: Palanosetron is safe, well tolerated and effective than Granisetron and Ondansetron in reducing the incidence of PONV with less need of rescue antiemetics. Key Messages: Palanosetron is proved better antiemetic than granisetron and ondansetron in prevention of PONV. Keywords: General Anaesthesia, Granisetron, Gynaecological surgery, Ondansetron, Palanosetron, Postoperative nausea and vomiting.
National Journal of Medical Research, 2018
Background: A randomized double blind study was conducted to compare efficacy of Ondansetron versus Granisetron among patients undergoing gynaecological surgery under the spinal anaesthesia. Objective: To compare Ondansetron and Granisetron for prevention of postoperative nausea and vomiting in patients undergoing gynaecological surgery under spinal anaesthesia. Material and methods: Total 60 consecutive patients, age between 18-58 years, ASA grade I and II undergoing gynaecological surgery under the spinal anaesthesia were randomized into two groups of 30 each. One group received I.V. Ondansetron 4.0 mg and the second received I.V. Granisetron 2.0 mg 5 minutes before induction of anaesthesia. For the first 24 hours postoperatively all episodes of nausea and vomiting were recorded. The observations were tabulated and analysed. Results: In this study found that during early postoperative period (0-3 hrs) there was no statistically significant difference in the study groups. Statistically significant difference was found in the study groups in the late postoperative period (3-24 hrs). Conclusion: In the early postoperative period both Ondansetron and Granisetron are equally effective in preventing postoperative nausea and vomiting in patients undergoing gynaecological surgery under spinal anaesthesia. Granisetron is better than Ondansetron in the late postoperative period of upto 24 hrs.
The Internet Journal of Anesthesiology
Post Operative Nausea Vomiting (PONV) is the most unpleasant and distressing consequence in the immediate post-operative period especially after general anesthesia. PONV can delay discharge and may result in unplanned over night hospital admissions. This is prospective randomized control study of 60 ASA grade I/II patients recruited at Seth G.S. Medical College to find out the efficacy, duration of action, haemodynamic stability, side effects of ondansetran and metclopromide lower the incidence of PONV in 24 hr of post operative period. The study was undertaken with an aim to investigate 1) The nausea and vomiting in immediate post operative period. 2) Efficacy of single dose I.V. injection of ondansetran (4mg) and metclopromide on PONV and 3) Side effects of these drugs. Early antiemetic efficacy abolition of vomiting after 1 , 4, 12 hrs was 3.66, 10 and 3.33% respectively from the administration of the study drugs with no further vomiting or nausea episodes after 24 hrs was in the ondansetron group. Similarly, abolition of vomiting after 1 , 4, 12 and 24 hrs was 20, 20 ,16.66 and 3.33 % respectively in the metoclopramide group compared to the placebo group (P < 0.001). This difference was still significant when controlling for age, body weight, history of motion sickness, previous PONV episodes, duration of anesthesia, and intraoperative fentanyl consumption using a logistic model. Therefore the overall results indicated that ondansetran is more effective than metchlopromide for the prevention of PONV.
European journal of anaesthesiology, 2015
Postoperative nausea and vomiting (PONV) can be prevented. Alizapride is an established antiemetic that may be effective in this role. Our primary objective was to test the hypothesis that alizapride is noninferior to ondansetron for the prophylaxis of PONV. A randomised, placebo-controlled, double-blinded noninferiority study. University hospitals of Leuven, Belgium, from November 2008 to July 2011. A total of 523 patients undergoing laparoscopic gynaecological surgery were included in the study. Reasons for exclusion were American Society of Anesthesiologists (ASA) greater than 2, hypersensitivity to the study medication, pregnancy, mental disorders, psychiatric illness or consumption of antiemetic drugs within 24 h before initiation of the study. Patients received either alizapride 100 mg, ondansetron 4 mg or placebo intravenously 30 min before the end of surgery. The main outcome measures included the incidences of postoperative nausea (PON) and postoperative vomiting (POV) duri...
Combination of ondansetron and dexamethasone in the prophylaxis of postoperative nausea and vomiting
British Journal of Anaesthesia, 1996
We studied 100 ASA I-II females undergoing general anaesthesia for major gynaecological surgery, in a prospective, double-blind, placebocontrolled, randomized study. Patients received one of four regimens for the prevention of postoperative nausea and vomiting (PONV): ondansetron 4 mg (n : 25), dexamethasone 8 mg (n : 25), ondansetron with dexamethasone (4 mg and 8 mg, respectively, n : 25) or placebo (saline, n : 25) There were no differences in background factors or factors related to operation and anaesthesia, morphine consumption, pain or side effects between groups. The incidence of nausea and emetic episodes in the ondansetron with dexamethasone group was lower than in the placebo (P : 0.01), ondansetron (P : 0.05) and dexamethasone (P : 0.057) groups. There were no differences between ondansetron and dexamethasone, and both were more effective than placebo (P : 0.05 and P : 0.01, respectively). Dexamethasone appeared to be preferable in preventing nausea than emetic episodes. Fewer patients in the ondansetron with dexamethasone group needed antimetic rescue (P : 0.01 vs placebo and P : 0.05 vs ondansetron). We conclude that prophylactic administration of combined ondansetron and dexamethasone is effective in preventing PONV. (Br.
Journal of Evolution of Medical and Dental Sciences
BACKGROUND The antiemetic action of 5-hydroxytryptamine receptor antagonists (5HT3 receptor blockers) has been well established. The present study compared the efficacy of the 5HT3 receptor blockers Ondansetron and Granisetron, in reducing the Post-Operative Nausea and Vomiting in day care gynaecological laparoscopic surgeries. Aims and Objectives-To compare the efficacy of intravenous Ondansetron versus Granisetron in the prevention of post-operative nausea and vomiting in patients undergoing day care gynaecological laparoscopic surgeries. MATERIALS AND METHODS 60 patients of ASA Grade 1 and II, between 18-55 years of age undergoing day care gynaecological surgeries were included in the present study. They were allocated into 2 groups of 30 each. The sample size was taken for convenience during the study. Group A received 4 mg (2 mL) of Ondansetron intravenously, Group B received 2 mg (2 mL) of Granisetron intravenously prior to induction of general anaesthesia. Each of these groups were assessed for the incidence of post-operative nausea, pain, emesis and adverse effects. RESULTS Incidence of nausea in the first 2 hrs. was the same in both the groups 16.6% (n= 5). The overall incidence of nausea in 0 to 24 hrs. in Group A and Group B was 23.3% (n= 7) and 20% (n= 6) respectively. The overall incidence of emesis in 0-24 hrs. after the surgery was found to be similar 6.6% (n= 2) in both the groups. No adverse effects were observed in both the groups. There was no statistically significant difference between Ondansetron and Granisetron with regards to their efficacy in minimising postoperative nausea and vomiting (p value > 0.05). CONCLUSION In conclusion, intravenous administration of 4 mg Ondansetron or 2 mg Granisetron prior to induction of general anaesthesia is equally effective in preventing the post-operative nausea and vomiting in day care gynaecological laparoscopic surgeries.