Cell apoptosis and hemodialysis-induced inflammation (original) (raw)

Cell apoptosis and hemodialysis-induced inflammation. Hemonuclear cells and may intensify the immunodeficiency dialysis patients exhibit a defective immune response leading response of such patients [5][6][7][8][9][10]. In this connection, for to an increased susceptibility of infections and neoplasms. Far the past 15 years, our group has been studying the immufrom being helpful, dialytic therapy per se also may be responsinomodulatory effects induced by hemodialysis. ble for this acquired immunodeficiency. Dialysis membranes and bacterial products present in dialysis water may trigger and even perpetuate an abnormal mononuclear cell activation. Upon contact with cellulosic dialysis membranes, monocytes display an increased expression of surface markers of cell acti- vation, such as adhesion molecules CD18, CD49, CD54 and Since our initial studies, we have demonstrated how the the lipopolysaccharide (LPS) ligand (CD14). Moreover, proinflammatory cytokines as IL-1␤ and TNF-␣ are released both