original ) (raw )Role of the E45K-reduced folate carrier gene mutation in methotrexate resistance in human leukemia cells
Jeffrey Taub
Leukemia, 2002
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Folate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate pharmacodynamics
Meyling Cheok
Journal of Clinical Investigation, 2005
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Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis
Herbert Pinedo
Biochemical Pharmacology, 2002
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Overexpression of folate binding protein α is one of the mechanism explaining the adaptation of HT29 cells to high concentration of methotrexate
celine chery
Cancer Letters, 2001
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Gene polymorphisms in folate metabolizing enzymes in adult acute lymphoblastic leukemia: effects on methotrexate-related toxicity and survival
Alessia Ongaro , G. Rigolin , M. Mattei , Donato Gemmati
Haematologica, 2009
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Effect of polymorphisms in folate-related genes on in vitro methotrexate sensitivity in pediatric acute lymphoblastic leukemia
Robert Jonge
Blood, 2005
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Disparate mechanisms of antifolate resistance provoked by methotrexate and its metabolite 7-hydroxymethotrexate in leukemia cells: implications for efficacy of methotrexate therapy
Alan Fotoohi
Blood, 2004
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Cytotoxic effects of folate antagonists against methotrexate-resistant human leukemic lymphoblast CCRF-CEM cell lines
Enrico Mini
Cancer Research, 1985
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Reduced folate carrier mutations are not the mechanism underlying methotrexate resistance in childhood acute lymphoblastic leukemia
Myriam Ben-Arush
Cancer, 2004
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Defective transport is a common mechanism of acquired methotrexate resistance in acute lymphocytic leukemia and is associated with decreased reduced folate carrier expression
Peter Steinherz
Blood, 1997
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Polymorphisms in folate-related genes: association with side effects of high-dose methotrexate in childhood acute lymphoblastic leukemia
Robert Jonge
Leukemia, 2008
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Glutathione levels are associated with methotrexate resistance in acute lymphoblastic leukemia cell lines
Carolina Pereira Souza Melo
Frontiers in Oncology
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Cytotoxic effects of folate antagonists against methotrexate-Resistam human leu-Kemic lymphoblast CCRF-CEM cell lines
Enrico Mini
Cancer Research
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Deregulation of folate pathway gene expression correlates with poor prognosis in acute leukemia
Mónica Saavedra-Herrera
Oncology Letters, 2019
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Associations of novel genetic variations in the folate-related and ARID5B genes with the pharmacokinetics and toxicity of high-dose methotrexate in paediatric acute lymphoblastic leukaemia
Andrea Harnos , Olivér Eipel
British Journal of Haematology, 2014
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Methotrexate Exacerbates Tumor Progression in a Murine Model of Chronic Myeloid Leukemia
Joel Frandsen
Journal of Pharmacology and Experimental Therapeutics, 2002
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Isolation of a Gene Encoding a Human Reduced Folate Carrier (RFC1) and Analysis of Its Expression in Transport-deficient, Methotrexate-resistant Human Breast Cancer Cells
Sarah Anzick
1995
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Molecular mechanism of antifolate transport-deficiency in a methotrexate-resistant MOLT-3 human leukemia cell line
S. Ivy
Blood, 1997
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Genetic polymorphisms of folate metabolic enzymes and toxicities of high dose methotrexate in children with acute lymphoblastic leukemia
Saowanee Kajanachumpol
Annals of Hematology, 2007
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Enhancing tumor response to targeted chemotherapy through up-regulation of folate receptor α expression induced by dexamethasone and valproic acid
Arnaud Monvoisin
Journal of Controlled Release, 2018
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Methylation-dependent Silencing of the Reduced Folate Carrier Gene in Inherently Methotrexate-resistant Human Breast Cancer Cells
Jesper Worm
Journal of Biological Chemistry, 2001
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Treatment of leukemia with large doses of methotrexate and folinic acid: clinical-biochemical correlates
Joseph Bertino
Journal of Clinical Investigation, 1969
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Large diversity in transport-mediated methotrexate resistance in human leukemia cell line CCRF-CEM established in a high concentration of leucovorin
Satomi Asai
Cancer Science, 2003
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Pharmacological and molecular investigations on the mechanisms underlying resistance of human leukaemia cells to the antimetabolites methotrexate, 6-mercaptopurine and 6-thioguanine
Alan Fotoohi
2007
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