A rare case presentation of eosinophilic granuloma treated with a novel approach: A case report and review of literature (original) (raw)
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Eosinophilic Granuloma in the Shaft of the Femur
TAJ: Journal of Teachers Association, 2011
Eosinophilic granuloma, the mildest from of histiocytosis appears in children, adolescents and young adults, though most patients present before ten years of age and it may be solitary of multiple. Most of lesions appear in the flat bone, in skull or in vertebral body. It may cause collapse of vertebra, which is called Vertebral plana. Eosinophilic granuloma in the diaphysis of femur is not common; so we are encouraged to report the case. DOI: http://dx.doi.org/10.3329/taj.v14i2.8394 TAJ 2001; 14(2): 88-89
Collegium antropologicum, 2013
Our aim is to provide review of available studies on Langerhans cell histiocytosis (LCH) and discuss treatment for polyostotic monosystem form of disease based on our clinical experience. LCH is an enigmatic disease with insufficiently understood etiology, pathophysiology, and variety of clinical presentations ranging from solitary eosinophilic granuloma to severe multisystem disease. It is marked by formation of granuloma in practically any organ. We present rare case of multifocal bone disease in 36-year old patient without visceral involvement. Treatment protocols for adult LCH patients, especially for uncommon form in our case have not yet been defined. Our therapeutical trial with corticosteroids showed limited success with numerous side-effects. We conclude that LCH treatment can commence only after diagnosis and staging of the disease. Other factors like patient's age, comorbidity, general condition, severity of symptoms and contraindications for therapy modalities should...
Clinical Rheumatology, 1999
We report a case of multifocal-monosystemic Langherhans cell histiocytosis (LCH), formerly usually referred to as eosinophilic granuloma (EG) of bone. The condition developed in a 36-year-old man. A notable infrequent thoracic spine location and two successive distinct costal lesions were observed. Both the first costal site and the vertebral location healed spontaneously; the second costal lesion underwent biopsy resection. The patient's disease course with an 8-year follow-up is discussed with reference to various treatment options, emphasising in selected cases a watchful conservative approach, in view of the widely documented potential for spontaneous healing.
Spontaneous Regression of Eosinophilic Granuloma
Abstract : Background: Langerhans Cell Histiocytosis (LCH) is a rare neoplasm characterized by abnormal proliferation of histiocytic cells. Primary tumorous lesions of the clavicle are very rare entity, and little literature is available regarding their characteristics and outcome. Though rarely reported, neoplasms of the clavicle occur, and their symptoms can be mistaken for more common shoulder conditions. We here present a case of Benign neoplasm of clavicle in a 4 year old child, presenting with complain of pain and swelling at the lateral end of clavicle. Patients Radiograph and MRI was done. Patients USG Guided FNA that was examined cytologically and was suggestive of Eosinophilic Granuloma. Patient was managed conservatively. At regular follow – up it was observed that the lesion reduced and the patient had a pain free lateral end of clavicle at the end of 2 years. Through work – up for common shoulder conditions often identifies incidental benign lesions of bone, the converse can be true. Persistent pain despite intervention should raise concern for further investigation. An x-ray alone can reveal a destructive bone lesion as the source of shoulder pain. Keywords : Eosinophilic Granuloma
Adult onset asynchronous multifocal eosinophilic granuloma of bone: an 11-year follow-up
Acta radiologica open, 2015
Multifocal eosinophilic granuloma (EG) is a rare observation within the spectrum of histiocytosis X, generally described in children. We report the case of a 33-year-old man with multifocal EG showing an asynchronous evolution of bone lesions during a follow-up of 11 years. We also present the therapeutic approach chosen for this patient and the repeated magnetic resonance imaging (MRI) examinations used to monitor the disease with a final favorable outcome.
Eosinophilic granuloma of the skull bone: a case report Langenharns cell granulomatosis
International Bulletin of Otorhinolaryngology
Eosinophilic granuloma is a rare benign tumor which is a variety of histiocytosis-X with unknown etiology. Eosinophilic granuloma occurs as single or multiple lesions of bone destruction. The eosinophilic granuloma of the skull can be asymptomatic or presented with pain and swelling. We present a clinical case of 20-years-old female patient who has entered the Neurosurgery clinic of "St. Marina" University Hospital with clinical manifestation of growing and painful tumor formation in the left frontal area for several weeks. MRI scan discovered evidence of a tumor formation on the left frontal side of the skull, suspicious for an eosinophilic granuloma. Under general anesthesia, an operative treatment was performed. Total extirpation of the tumor mass was achieved and cranioplasty with titanium mesh of the bone defect was performed. Posteratively, the patient had a good cosmetic effect, she was mobilized on the first day after the intervention and discharged from the hospital on the 5th day. Surgery-related complications were not observed. In the postoperative period the patient was followed-up by a hematologist. It is important and recommended for clinicians to include eosinophilic granuloma in the differential diganosis of bone lesions in patients because of the possible expansion of the disease if untreated. A follow-up of a year is necessary for possible recurrence.
Solitary eosinophilic granuloma of the lumbar spine in an adult. Case report
Spinal Cord, 1995
Eosinophilic granuloma of bone is the localised and most benign form of Langerhans-cell histiocytosis, previously known as histiocytosis X and is characterised by lytic lesions of one or more bones. It is a disease of children and adolescents, and very rarely affects adults. We report a 34-year-old patient with a solitary eosinophilic granuloma involving the fifth lumbar vertebra which produced sciatica. Operative treatment performed by a single extended posterior approach consisted of total resection of the tumour with hemicorpo recto my , L4-5 and L5-S1 discectomy, interbody fusion with an iliac bone graft, and interpedicular fixation, Postoperatively, the symptoms resolved and the patient continues to do well at 2� years follow-up,
Management of eosinophilic granuloma localized in the pelvis and extremities
The Annals of Clinical and Analytical Medicine, 2020
Aim: Given the benign biology, and clinical course of eosinophilic granuloma and its higher incidence in pediatric patient group, a successful treatment plan with lower risk for complications is desired. In this study, we aimed to evaluate clinical characteristics, treatment, and outcomes of patients diagnosed with eosinophilic granuloma localized in the pelvis and extremities. Material and Method: Clinical findings, treatment methods, clinical outcomes and treatment failures were evaluated in a total of 19 patients (6 males, 13 females, mean age: 16.5 years, range: 1-37 years) diagnosed with eosinophilic granuloma localized in the pelvis and extremities between 2002 and 2016. Results: The most common mass localization was acetabulum (15%, n = 3). The mean tumor size was 3,7 cm (range: 1-8 cm). All patients presented with pain and had primary tumor. All patients in the study had solitary bone lesion. The mean duration of postoperative follow-up was 46 months (range: 24-95 months). Three patients underwent biopsy alone, and followed-up with adjuvant therapies. In 14 patients, curettage of the lesion was performed at single session during biopsy, and grafting was applied in six of these patients. Two patients underwent excision of the lesion. None of the patients developed recurrence, while a new lesion was detected in the cervical vertebra in one patient after treatment of acetabulum localized lesion. Discussion: The management of eosinophilic granuloma localized in the pelvis and extremities takes place in a wide spectrum varying from observation alone, to lesion curettage, chemotherapy and radiotherapy applications, and prophylactic administration, and treatment tailored for each patient should be planned with a multidisciplinary approach.
Solitary eosinophilic granuloma of the parietal bone in an adult patient
Neurosciences (Riyadh, Saudi Arabia), 2007
Eosinophilic granuloma (EG) is a well-recognized benign form of Langerhans-cell histiocytosis. The estimated incidence of EG is 3-4 per million of the population. More patients are children and adolescents between the ages of 1-15 years. In this report, we present an adult patient. A 37-year-old male was admitted with headache and right parietal swelling that was present for 2 months together with epileptic attacks. Cranial CT scan revealed a right parietal osteolytic lesion with large epidural and subcutaneous mass, causing brain compression. Total removal of the mass was carried out with cranioplasty. Histopathological examination disclosed Langerhans cell histiocytosis and immunohistochemical detection of S-100 antigen. At follow-up, he had no neurological deficits, and control CT was normal. For symptomatic solitary calvarial EG, surgical excision is the main treatment option. Surgical treatment is simple, quick, and allows histological diagnosis of the osteolytic lesions.