© 2012 Landes Bioscience. Do not distribute. Evolution of the let-7 microRNA Family (original) (raw)

2012

Abstract

he increase of bodyplan complexityin early bilaterian evolution is corre-lates with the advent and diversificationof microRNAs. These small RNAs guideanimal development by regulating tem-poral transitions in gene expressioninvolved in cell fate choices and transi-tions between pluripotency and differenti-ation. One of the two known microRNAswhose origins date back before the bilate-rian ancestor is mir-100. In Bilateria, itappears stably associated in polycistronictranscripts with let-7 and mir-125, twokey regulators of development. In verte-brates, these three microRNA familieshave expanded to form a complex systemof developmental regulators. In this con-tribution, we disentangle the evolutionaryhistory of the let-7 locus, which wasrestructured independently in nematodes,platyhelminths, and deuterostomes. Thefoundation of a second let-7 locus inthe common ancestor of vertebrates andurochordates predates the vertebrate-specific genome duplications, which thencaused a rapid expansion...

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