Examples of microRNA gene duplication histories (original) (raw)

2011

Abstract

<b>Copyright information:</b>Taken from "The expansion of the metazoan microRNA repertoire"BMC Genomics 2006;7():25-25.Published online 15 Feb 2006PMCID:PMC1388199.Copyright © 2006 Hertel et al; licensee BioMed Central Ltd. (a) Gene tree and most plausible reconstructed history of the cluster. The fourth member of the cluster, , evolves rapidly in flies. Its homology with /is likely but this hairpin might also have evolved . (b) The two most plausible reconstructions for the history of the cluster. Scenario (1) postulates four paralogs in the ancestral vertebrate, where, presumably after the first duplication, one lineage either lost or gained in the middle position of the cluster. Subsequently, in this scenario one copy of the three-membered cluster was lost in actinopterygians, while the two-membered clusters were lost in tetrapoda. Scenario (2) postulates three paralogs in the ancestral vertebrate and the independent loss of the in two distinct clusters in the teleosts. (c) Duplication history of the cluster reconstructed from genomic position information and the gene tree.

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