(a) All microRNAs in the cluster appear to have arisen from a common ancestral sequence (original) (raw)

2011

Abstract

<b>Copyright information:</b>Taken from "The expansion of the metazoan microRNA repertoire"BMC Genomics 2006;7():25-25.Published online 15 Feb 2006PMCID:PMC1388199.Copyright © 2006 Hertel et al; licensee BioMed Central Ltd. The individual paralog groups have diverged rapidly in the ancestor of extant eutherian. Surprisingly, there is very little sequence variation between human and rodents in each of the paralog groups. The six families of alignable microRNAs are indicated in color. (b) WPGMA dendrogram derived from pairwise -scores of the members of the cluster. The analysis of the mature sequences demonstrates that the members of the cluster probably have arisen by means of tandem duplications.

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