Clear cell “sugar“ tumor of the lung — case report (original) (raw)
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Clear cell "sugar" tumour of the lung: a case report
The Malaysian journal of pathology
We report a case of clear cell "sugar" tumour of the lung (CCTL) occurring in a 26-year-old lady. The patient was asymptomatic and the lesion was picked up in the course of a pre-employment medical examination. A well-defined 5 cm nodule in the right lower lobe was detected on routine chest X-Ray. Microscopical examination of the coin lesion showed clear cells containing abundant diastase-sensitive intracytoplasmic glycogen, as demohstrated with periodic acid-Schiff stains. Tumour immunoreactivity for HMB-45 and non-reactivity for cytokeratin support the histological diagnosis. To our knowledge, this is the first reported case of CCTL in Malaysia.
Clear cell “sugar tumor” of the lung: Diagnostic features of a rare pulmonary tumor
Respiratory Medicine Case Reports, 2018
Clear cell tumor of the lung (CCTL) is an extremely rare neoplasm with about 50 cases reported in the literature so far. CCTL belongs to a family arising from putative perivascular epithelioid cells and is otherwise named as "sugar tumor" due to its high cellular glycogen concentration. Due to its rarity, diagnostic features of this entity are not widely known and this usually leads to misdiagnosis. Herein, we report a case of benign CCTL, which was primarily evaluated intraoperatively by FNA cytology and then by a pathological examination of the resected tumor. The cytologic preparations were moderately cellular and showed multiple large, irregular, cohesive clusters of ovoid or spindle tumor cells. Cells had clear cytoplasm, showing positivity with the periodic acid-Schiff (PAS) staining method owing to the glycogen (sugar) content. The rapid cytologic report excluded the possibility of malignancy and a middle lobectomy along with an anterior upper segmentectomy was performed. Immunochemistry revealed a diffuse positivity for HMB45, MART-1, SMA and focally for desmin, while specimen was negative for pancytokeratin cocktail AE1/AE3, cytokeratin7, cytokeratin20 and EMA. These findings confirmed the diagnosis of a benign CCTL. Due to its rarity and similarity with other clear cell tumors of the lung, awareness of this entity, recognition of the cytomorphologic features and familiarity with the associated clinical features can help clinicians avoid certain pitfalls in the diagnostic process. Considering its benign course, unnecessary extensive lung resections may also be avoided thus permitting conservative management of these patients.
Annals of Diagnostic Pathology, 2007
Clear cell “sugar” tumor (CCST) of the lung is a very rare benign neoplasm believed to arise from epithelioid cells of perivascular differentiation. This tumor is typically diagnosed by thoracotomy. To our knowledge, only 2 case reports of CCST have been previously published: one case in which cytologic findings were subsequently confirmed histologically and ultrastructurally to be CCST, and one case of CCST diagnosed preoperatively by transbronchial core-needle biopsy. We here depict an additional case of CCST of the lung that was preoperatively diagnosed by computed tomography–guided transthoracic fine-needle aspiration biopsy and core-needle biopsy. We underscore the importance of cytologic and histologic correlation and the role of ancillary studies in differentiating this lesion from other primary or metastatic clear cell tumors of the lung.
A rare cause of hemoptysis: benign sugar (clear) cell tumor of the lung
European Journal of Cardio-Thoracic Surgery, 2004
A case of benign sugar (clear) cell tumor of the lung with an unusual clinical presentation and its evaluation with computed tomography are reported. A 48-year-old man presented with one episode of hemoptysis. Chest radiographs revealed a round nodule in the lower left lung lobe, and fiberoptic bronchoscopy was normal. On the computed tomography scans, the nodule showed intense post-contrast enhancement (74.7 Hounsfield units). The patient underwent a left thoracotomy, and a segmentectomy was performed. Pathologic examination showed a benign sugar cell tumor of the lung. The patient is alive and has remained free of disease for the last 2 years. To the best of our knowledge, this is the first case report of sugar cell tumor located in lung parenchyma that presented with hemoptysis and the second report of the contrast-enhanced computed tomography findings in this neoplasm. q
Early clear cell “sugar” lung cancer management: A case report and a brief literature review
Thoracic Cancer
A clear cell tumor is a histological entity that rarely originates outside of the kidney. We describe a rare case of a clear cell tumor of the lung, also known as "sugar cancer," that occurred in a 74 year-old male patient, and perform a brief literature review. This report highlights the importance of an adequate disease management team, including surgeons, oncologists, and pathologists, to identify the best therapeutic approach to improve survival rates and the quality of life of patients affected by this rare disease.
Primary clear-cell carcinoma of the lung
Respiratory Medicine, 1993
IlltrOdUCtiOll Primary clear-cell carcinoma of the lung is defined as a malignant epithelial neoplasm composed on histopathological examination largely of optically clear non-mucin producing cells without evidence of squamous differentiation (1). It is classified by the World Health Organisation as a variant of large-cell carcinoma. The presence of a few clear cells is not sufficient to make the diagnosis as they are said to occur in up to 10% of large-cell carcinomas that elsewhere show evidence of squamous or glandular differentiation (2). There are few reports of clear-cell carcinoma in the English literature (24), and it is the purpose of this study to describe two further cases, and particularly to stress some of the practical diagnostic problems. Case Reports CASE 1
Clear Cell `Sugar' Tumor of the Breast
The American Journal of Surgical Pathology, 2002
A group of lesions show morphologic and immunophenotypic evidence of differentiation toward a putative perivascular epithelioid cell. These so-called PEComas include angiomyolipoma, lymphangiomyoma, lymphangioleiomyomatosis, renal capsuloma, clear cell myomelanocytic tumor of the falciform ligament/ligamentum teres, and clear cell "sugar" tumor. PEComas are characterized by strong immunoreactivity with the HMB45 antibody and variable expression of muscle markers. This family of lesions may be composed of a spectrum of cells from epithelioid to spindle cells with clear to granular eosinophilic cytoplasm. One member of this family, composed of epithelioid cells with glycogen-rich clear cytoplasm, is descriptively called a clear cell "sugar" tumor. This tumor, originally described in the lung, is being recognized increasingly in extrapulmonary sites. We report a case of a primary extrapulmonary clear cell "sugar" tumor occurring in the right breast of a 16-year-old girl. The tumor was composed of clear epithelioid cells with abundant glycogen and distinct cell borders. The tumor showed strong immunoreactivity with HMB45 antibody and Melan-A. There was focal vimentin staining. In addition, there was diffuse and strong nuclear staining for progesterone receptor. Antibodies to actins, S-100 protein, cytokeratins (AE1/AE3 and CAM5.2), desmin, and estrogen receptor were negative. The tumor was completely excised, and the patient is well without evidence of disease 9 months postexcision.
Primary clear cell carcinoma of the lung with salivary gland type features
Boletín de la Asociación Médica de Puerto Rico, 2014
Clear cell carcinoma of the lung is very rare, with few cases reported in the medical literature. Review of case studies show that these tumors have significant variation in clinical outcome, including metastatic disease. We present a very unusual case of primary clear cell lung carcinoma of salivary gland type.
Journal of Cancer Research and Therapeutics, 2010
Perivascular epithelioid cell tumor (PEComa), also called clear cell ''sugar'' tumor of the lung, is a rare benign tumor arising from perivascular epithelioid cells (PECs). We report a case of a 15-year-old boy who presented with right lower lobe lesion which turned out to be a clear cell tumor of the lung. An [18F]-fluoro-2-deoxy-D-glucose (FDG)-positron emission tomography (PET) scan revealed mild FDG uptake in the lung lesion (SUV<1) with no active uptake elsewhere in the body. We discuss the clinical, radiologic and immunohistochemical features of clear cell ''sugar'' tumor of lung and compare them with published literature.
Fine needle aspiration cytology of clear cell sarcoma of the kidney with spindle cell pattern
Cytopathology, 2003
PEComa (clear cell ''sugar'' tumor) of the lung is a rare benign tumor of the lung probably arising from the perivascular epithelioid cells (PECs). We report a case of pulmonary PEComa arising from the periphery of the right lobe of a 64-year-old male. To our knowledge, this is the second case in the English literature diagnosed by fine needle aspiration biopsy. In this case report, the clinical, cytologic and immunohistochemical features clear cell ''sugar'' tumor of the lung are discussed and compared with the previously published literature. The differential diagnosis and methods for distinguishing the various clear cells lesions in the lung are discussed. Diagn. Cytopathol. 2008;36:89-93. '