Synthesis of biomimetic Ca-hydroxyapatite powders at 37°C in synthetic body fluids (original) (raw)

An important inorganic phase for synthetic bone applications, calcium hydroxyapatite (HA, Ca (PO) (OH)), was prepared as a nano-sized (&50 nm), homogeneous and high-purity ceramic powder from calcium nitrate tetrahydrate and diammonium hydrogen phosphate salts dissolved in modi"ed synthetic body #uid (SBF) solutions at 373C and pH of 7.4 using a novel chemical precipitation technique. The synthesized precursors were found to easily reach a phase purity '99% after 6 h of calcination in air atmosphere at 9003C, following oven drying at 803C. There was observed, surprisingly, no decomposition of HA into the undesired-TCP phase even after heating at 16003C in air for 6 h. This observation showed the superior high-temperature stability of such &biomimetic' HA powders as compared to those reported in previous studies. The former powders were also found to contain trace amounts of Na and Mg ions, originating from the use of SBF solutions instead of pure water during their synthesis. Characterization and chemical analaysis of the synthesized powders were performed by X-ray powder di!raction, energy-dispersive X-ray spectroscopy, Fouriertransform infra-red spectroscopy, scanning electron microscopy, and inductively coupled plasma atomic emission spectroscopy.

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