5 th International Congress on Cell Membranes and Oxidative Stress: Focus on Calcium Signaling and TRP Channels (original) (raw)

2014

Abstract

Neuropathic pain can arise from a wide variety injury to peripheral, including metabolic disorders, traumatic injury, inflammation, and neurotoxicity, and is characterized by spontaneous pain, hyperalgesia and allodynia which can persist long after the initial injury is resolved. TRPV1 is a Ca2+ permeable non-selective channel expressed in sensory neurons. Moreover, activation of TRPV1 during oxidative stress has been linked to cell death. Selenium has been considered a potent antioxidant that detoxifies a variety of reactive oxygen species in many neurological diseases. In addtion recently we observed modulator role of selenium on TRP channels in dorsal root ganglin (DRG) neuron of rtas. In order to better characterize the actions of selenium in the peripheral pain, we tested the effects of selenium on apoptosis, oxidative stress and calcium entry through TRPV1 channel in the DRG neuron of streptozotcin (STZ)induced diabetic rats. Sixty rats were randomly divided into four groups. ...

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