Vitamin D status in mothers and their newborns in Iran (original) (raw)
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Vitamin D Deficiency among Pregnant Women and Their Newborns in Isfahan, Iran
Experimental and Clinical Endocrinology & Diabetes, 2008
37 ° 32 Ј N) and general population of Tehran (lat 36 ° 21 Ј N) [8, 11 -14] . A study on pregnant women in 2002 -2003 in Tehran has found that 60 % of them in the fi rst trimester, 48 % in the second and 47 % in the third trimester had either severe(25(OH)D level < 10 ng / ml) or moderate(25(OH)D level < 20 ng / ml) vitamn D defi ciency and another study in 1997 in Tehran found a prevalence of 80 % for vitamin D defi ciency(25(OH)D level < 10 ng / ml) in women at delivery time [15 -16] . Considering the lack of data about vitamin D defi ciency in Isfahani pregnant women and their newborns, we conducted this study to investigate the status of vitamin D in pregnant women and their newborns at labor time in the largest obstetric center in Isfahan. The other goal was to study the correlation between vitamin D deficiency and some serum markers as well as social and demographic factors.
Study of Vitamin D Status in Pregnant Women in North of Iran
International Journal of Women's Health and Reproduction Sciences, 2016
Introduction Vitamin D is one of the most important and necessary vitamins for body. It has physiological role in metabolism and structure of body (1,2). It plays an important role in regulating cell proliferation and differentiation, muscle function, heart, metabolism system and adaptive immune responses (3,4). The vitamin D metabolic procedure involves multiple enzymatic reactions. The most important role of vitamin D is in metabolism process through the liver to form 25(OH)D. 25(OH)D is metabolized in the kidneys by 25-hydroxy vitamin D-1 alpha hydroxylase (CY-P27B1) and changed into its active form, 1,25-(OH) 2 D (5). In addition,vitamin D during pregnancy not only has important physiological role in metabolism and structure of body but also affects the bones, teeth and growing fetal brain (6). Moreover, it modulates human reproductive processes (7). The function of vitamin D during pregnancy for both mother and fetus remains largely undefined (8,9). Nutrition during pregnancy is the most important and controllable factor which can protect women against the induction and progress of different diseases. Studies show that foliate, folic acid, calcium, vitamin D, iron and other supplements are important during pregnancy. Sufficient levels of vitamin D in mother's body during pregnancy can decrease diabetes type I, asthma, bone problems, systematic auto immune diseases and other maternal and fetal morbidities (10-15). Additionally, the impact of less severe vitamin D deficiency and insufficiency has received much interest in recent years (16,17). There is evidence of early interest in relationship between vitamin D status and prenatal health outcomes (18). Maternal vitamin D status influences bone health in the baby (19). Studies have demonstrated associations between low levels of serum 25(OH)-vitamin D during pregnancy and maternal and fetal health outcomes (20). Vitamin D can prevent transfer of infection which is as an important factor in outcome of pregnancy as an early delivery. Vitamin D, acts as a key influencing factor during pregnancy. Study showed 25(OH)-vitamin D can suppress a broad range of cytokines and inhibit inflammatory process in placenta (21). Also studies showed a positive association between in deficiency of vitamin D with increasing preeclampsia (22,23) and diabetes (12,24). Studies in Iran reported that vitamin D deficiency in pregnant women is 60%-86% (20-25). Vitamin D deficiency is common in whole world but there is difference in different countries.
Vitamin D status in pregnant women and their newborns in a tertiary care hospital
International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2018
Background: In the recent years there has been an increased understanding of the role that vitamin D plays in regulation of cell growth, calcium absorption and immunity and its impact on the developing fetus and maternal health is of significant concern. This study aims at evaluating the Vitamin D status in pregnant women and their newborns.Methods: A cross sectional study was done on 100 pregnant females according to inclusion and exclusion criteria. At the time of delivery, maternal blood was collected, and newborn samples were taken from newborn side of umbilical cord and sent for analysis.Results: The prevalence of Vitamin D deficiency has been found to be 85% of pregnant females and 91% of the newborns. Only 5% of pregnant females and 1% of the newborns showed Vitamin D sufficiency. Maternal and newborn vitamin D levels show a positive correlation. Mean maternal and newborn Vitamin D levels were found to be 16.78±7.04 ng/mL and 11.29±5.75 ng/ml.Conclusions: Vitamin D deficiency...
Vitamin D deficiency in pregnant women and their neonates in spring time in western Turkey
Paediatric and Perinatal Epidemiology, 2012
Background and Objective: Vitamin D deficiency during pregnancy is a worldwide problem. Studies have reported prevalence ranged 18-84% in pregnant women. Receiving adequate calcium and vitamin D during pregnancy period is necessary for calcium homeostasis, fetal growth and bone mineralization. This study was aimed to determine the prevalence of vitamin D deficiency in pregnant women and their neonates in Shahroud city in the northeast Iran. Methods: In this cross-sectional study, 284 pregnant women and their neonates referred to Fatemiyeh Hospital of Shahroud were included. Blood samples of mothers and umbilical cords were collected during the delivery and were sent to laboratory in order to measure calcium and 25-hydroxy vitamin D. Findings: Amounts of Vitamin D insufficiency (20-30 ng/mL) and deficiency (<20 ng/mL) in (mothers, neonates) were found to be (60.2%, 48.9%) and (1.1%, 2.5%) respectively. Calcium deficiency (<8.5 mg/dL) was present in 33.5% of mothers and 25% of neonates. There was a weak correlation between maternal serum and cord blood 25-hydroxy vitamin D (r=0.12, p=0.053). Conclusion: More than half of the mothers and their neonates had some degrees of vitamin D deficiency. It is recommended to evaluate the nutritional status of vitamin D in pregnant women along with public health interventions to be carried out.
Impact of Maternal Severe Vitamin D Deficiency on Fetal Outcome
Scholars Journal of Applied Medical Sciences, 2020
Original Research Article Vitamin D is known to play an important role in bone metabolism and immune system regulation. Objective: to evaluate the impact of maternal vitamin D level on Baby hematological & anthropometric measurements. Patients and methods: prospective cross sectional study was conducted on 22 women with their babies who delivered vaginally at AL-Jamhoria hospital labour room with gestational age ˃ 37 week. The verbal consent was taken with Full out the questions Form. Maternal venous blood for biochemical (vitamin D, PTH, s. Ca+, s. Po4, s. Alk. Ph) & baby venous blood for biochemical (vit. D, s.Ca+, s. PO4, s. Alk. Ph) and anthropometric measurements (B. weight, Length, Head circumference) were taken immediately after birth by same person. Results and Conclusion: 22 women with their babies, aged between 19-42 year with mean (31.5± 5.83) where 5 (22.7 %) 0f them received vitamin D injection during pregnancy. Mean maternal vitamin D & parathyroid hormone levels were (3.29± 1.36 & 53.2± 2.2) respectively, the mean maternal calcium, phosphate & Alkaline phosphatase were {(8.5± 0.42), (3.66± 0.46), (77.5± 2.2)} respectively. The mean baby vitamin D level is 3.75± 2.04 where10 (45.5%) of babies had features of vitamin D. The mean baby calcium, phosphate, Alkaline phosphatase were {(9.20± 0.56), (5.20± 0.7), (93.5± 3.20)} respectively. The mean baby birth weight, Length, Head circumference were {(3.35± 0.45), (49.95± 1.17), (34.79± 1.08)} respectively. The significant correlation were exists between Maternal vitamin D & baby vitamin D & between Maternal parathyroid hormone & Baby Alkaline phosphatase.
Saudi medical journal
Objectives: To evaluate the nutritional status of vitamin D in relation to calcium-regulating hormones and related minerals. Methods: A cross-sectional study was conducted on 264 Saudi pregnant females and their babies (at term) living in the Jeddah area. Maternal and fetal concentrations of serum calcidiol and calcitriol were determined together with those of serum intact-PTH, calcitonin, HPL, prolactin, DBP, alkaline phosphatase, calcium, phosphate and magnesium.
Human Antibodies, 2020
BACKGROUND: Calcium and vitamin D deficiency is common among Iranian women of childbearing age and poses adverse effects on pregnancy outcomes. The aim of the current study was to determine the prevalence of vitamin D and calcium in a sample of Iranian pregnant women and to assess its correlation with the feto-maternal outcomes. METHODS: In this prospective cross-sectional study, a sample of pregnant women between 15 to 45 years who were in the third trimester were recruited from a number of hospitals in Tehran. Data were collected by the means of a self-developed questionnaire, interviews, physical examination, and paraclinical tests including measuring the serum level of calcium, vitamin D, parathormone (PTH) and phosphorous (Pi). The questionnaire obtained information on age, level of education, socio-economic status, parity, gravidity, calcium intake during pregnancy, as well as feto-maternal outcomes. RESULTS: We included a total number of 233 singleton pregnancies. Most of the...
International journal of reproduction, contraception, obstetrics and gynecology, 2016
Vitamin D deficiency during pregnancy is a worldwide epidemic; studies have reported a prevalence that ranges from 18-84%, depending on the country & local clothing customs. 1-5 Vitamin D deficiency is common in darkskinned persons, veiled populations living at various latitudes and inadequate vitamin D intake in women of ABSTRACT Background: The aim of our study was to determine the prevalence of vitamin D among pregnant women and its impact on feto maternal outcome. Methods: An observational study was conducted among 80 pregnant women at PESIMSR, Kuppam over a period of one month from first September 2014 to 30th September 2014. Our primary outcome was to study prevalence of Vitamin D deficiency in pregnant women and secondary outcome to study maternal and fetal outcome in pregnant women with Vitamin D deficiency. The subjects participating in the study were requested to complete a questionnaire that covered socio-demographic data, religion, obstetric history, lifestyle, dietary habits and psychosocial factors. Reliable serum 25-hydroxyvitamin D (25(OH) D) level was measured using an enzyme immunoassay method in the extra nine ml blood sample. Data on date of delivery, baby sex, birth weight, length and gestational age (based on ultrasound or on the timing of the last menstrual period) were collected prospectively. Results: In the study period of the 80 women recruited, 3.8% were Christians, 78.8% were Hindus and 17.4% were Muslims. All women recruited for the study were >32 wks gestation. It was found that 53.8% had insufficient serum 25 (OH) D concentrations and 13.8% were deficient for vitamin D. The lowest 25(OH) D concentrations (insufficient levels) were found in those with only one-two hours of sun exposure (65.1%), and 54.5% had deficient levels. Highest concentrations (11.5%) were found in those with two-four hours of sun exposure. There were no significant associations between 25(OH) D concentrations and maternal outcome. The analysis showed a significant association between a deficient vitamin D status (45.5%) and low birth weight (<2.5Kg) compared to 15.4% who had normal vitamin D levels. An insufficient vitamin D status was also related to a lower birth weight, but the association was not statistically significant. Among babies born to study subjects 84.6% had a normal birth weight of 2.5-3.5 kg with normal maternal vitamin D levels, when compared to 36.4% with deficient maternal vitamin D levels. We did not find any significant association between Vitamin D levels and neonatal complications. Conclusions: In our pilot study we found that prevalence of vitamin D deficiency was very high. Our sample size was too small to comment on impact of vitamin D deficiency on fetomaternal outcome. Hence we stopped our study and considered universal supplementation to all pregnant women.
2020
In Pakistan there is limited evidence for the levels and relationship of 25 (OH) Vitamin D [25(OH)D] status in pregnant women and their newborns while the association between maternal 25(OH)D and newborn anthropometric measurements remains unexplored. Sociodemographic data was collected from 213 pregnant mothers during their visit to a tertiary care hospital at the time of childbirth. Anthropometric measurements were performed on all mothers and their newborns and blood samples collected from both for 25(OH)D levels. Participants were classified into two groups according to their 25(OH)D status: Sufficient (25(OH)D ≥50nmol/l) and Deficient (25(OH)D 0.05). Our study shows a high prevalence of 25(OH)D deficiency in pregnant women and their newborns and a strong positive association between maternal and newborn 25(OH)D levels. Findings of this study indicate the importance of maintaining sufficient 25(OH)D levels during pregnancy.
International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2016
Background: From conception the embryo is dependent on the mother for all nutritional requirements until birth. Vitamin D deficiencies have adverse effect on pregnancy outcome result in poor growth, prematurity, NTD, even congenital anomalies. The aim and objectives of the study was to assess the prevalence of deficiencies among pregnant woman attending M.Y. Hospital and assess the correlation with the pregnancy complications.Methods: Total 110 patients were studied for vitamin d levels and associated obstetrical complications and risk factors over a period of six months. 53 pregnant women were found to be deficient with vitamin D.Results: 53 pregnant women out of total of 110 were deficient in vitamin D levels. Maximum patients belonged to group (21-30yr) of age. Vitamin D deficiency was more in housewives (65.3%) and in urban(86.8%). Low birth weight<2.5kg were born 50(45.5%) and 2 IUD. 2 were diagnosed NTD in USG reports. 80% low birth weight babies were born in vitamin D defi...