Frequency of severe liver cirrhosis and hepatocellular carcinoma caused by hepatitis B and C in a tertiary care hospital (original) (raw)
Related papers
Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
Despite bearing the main burden of HCC, prospective studies from developing countries are lacking. This prospective observational study was designed to estimate the incidence of HCC among Indian patients with hepatic cirrhosis. Between April 2001 and November 2004, we enrolled 301 patients with liver cirrhosis. Patients found to be free of HCC using baseline abdominal ultrasound, triple-phase computed tomography (TPCT) and serum alpha-fetoprotein (AFP) levels were followed up prospectively for detection of HCC using ultrasound and AFP every 6 months, and TPCT annually. Among the 194 patients (mean age [SD] 45.1 [+/-13.1] years; male:female 6.1:1.0) followed up, 154 had Child's A and 40 had Child's B disease. The causes of cirrhosis were: hepatitis B-71 (36.6%), hepatitis C-54 (27.8%), dual infection with hepatitis B and C-12 (6.2%) and others including autoimmune, alcoholic and cryptogenic cirrhosis 57 (29.4%). During a cumulative follow up period of 563.4 person-years, 9 ca...
International Journal of Research in Medical Sciences, 2015
the X protein of HBV is a potent transactivator that can interact with p53, interfering with its tumor-suppressor activity. 8 Cirrhotic patients have a higher risk than noncirrhotic patients with annual HCC incidences 2-6.6% and 0.4% respectively. Worldwide, 380 million individuals are infected with hepatitis B and 170 million ABSTRACT Background: Hepatocellular Carcinoma is the 5 th most common neoplasm in the world and 4 th most common cancer death. Most patients with HCC have an underlying chronic liver disease (often cirrhosis), resulting mainly from chronic infection by Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), excessive alcohol consumption, and often an association of these causes. HCC has recently gained more interest due to its increasing incidence in industrialized countries. Objective: To determine the frequency of hepatocellular carcinoma in hepatitis C reactive cirrhotic patients. Methods: Place and duration of study: Department of medicine, civil hospital Karachi. Duration: Six months from 16-12-2012 to 15-6-2013. Subjects and methods: Patients admitted in medical wards of civil hospital Karachi with liver cirrhosis due to hepatitis C virus were included in the study. Investigation relevant to hepatocellular carcinoma like alpha fetoprotein and ultrasound was performed. If the Alpha fetoprotein is greater, then 200 ng/ml in the setting of a mass in a cirrhotic liver the likelihood of hepatocellular carcinoma is greater then 90% and biopsy is not required. Results: Overall mean age was 41.1 ± 7.1 years with Male:Female = 4.2:1. Out of 141 cases; hepatocellular carcinoma was diagnosed in 8 (5.7%) of patients with HCV related cirrhosis with mean age 48.6 ± 6.4 years. Proportion of hepatocellular carcinoma was high 7 (6.1%) in male. 7 (6.4%) cases had child pugh-C, 1 (5%) case had child pugh-B and while no HCC was seen in child pugh-A. Conclusion: In this study hepatocellular carcinoma was 5.7% in cases with hepatitis-C induced cirrhosis. Older age (>54 years), male sex and child pugh-C were predominant factors leading to hepatocellular carcinoma.
Hepatitis Monthly, 2012
This review will demonstrate the epidemiological pattern and distribution of HBV and HCV and clarify their roles as risk factors to HCC, with the consequence of HCC distribution throughout the world. Context: Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections constitute a major global health problem. About 60,000 and 350,000 deaths occur as the results of HBV and HCV infections, respectively. Chronic hepatitis B and C infections are leading causes of cirrhosis and hepatocellular carcinoma (HCC) which are considered as the third cancer-associated cause of deaths worldwide. Iran suffers from the same problem but to a lesser extent as it is considered as a low endemic area for HBV and HCV infections and also as a low incidence area of HCC. This study was conducted to assess and provide a clear picture about epidemiology of HBV and HCV infections in Iran and worldwide, with the consequence on HCC distribution all over the world including Iran, and to analyze current literature regarding the modes of transmission and risk factors of HBV and HCV infections. Evidence Acquisition: In this review, we performed electronic and manual searches on available databases such as MEDLINE, PubMed, Ovid, Embase, and the Iranian databases such as IranMedex. We also performed a Google search to find related articles. Results: HBV and HCV infections are the most common risk factors of hepatocellular carcinoma. The epidemiology of HCC usually follows that of HBV and HCV infections. With the introduction of HBV national vaccine in Iran and worldwide, there is a noticeable effect on reduction in HBV prevalence in most countries, and we expect that HCV will replace HBV as a major risk factor of HCC in Iran and worldwide. Alcohol plays a minor role as a risk factor for cirrhosis and HCC in Iran, Asia, and Africa, despite its noticeable role in Europe and the USA. Conclusions: Vaccination against HBV remains the most effective approach against HBV infection with consequence decrease in HBV-related HCC. There is a need to improve the awareness about epidemiology of HBV and HCV infections, modes of transmission, and their complications, specifically HCC among population.
Clinical profile of cirrhosis of liver in a tertiary care hospital of Assam, North East India
2016
Background: Epidemiology of liver cirrhosis suggests that although Hepatitis B and C are still common in developing countries, alcohol related cirrhosis is increasing. Rising trends in alcohol consumption in North East India, makes it essential to analyse the influence of these changes in the epidemiology of liver cirrhosis. Therefore, we aimed to study one thousand patients of cirrhosis of liver in North East India with reference to its demography, aetiology, clinical presentation, complications, prognostic features and short term mortality. Materials and methods: One thousand consecutively diagnosed adult cirrhosis patients were prospectively studied at the Department of Gastroenterology, Gauhati Medical College, a tertiary care hospital of North East India from June 2013- May 2014 for their clinical characteristics, prognosis and mortality at one month. Results: Commonest age group was 35-54years, mean age 45.8+ 10.4 years; M: F ratio 7.5:1. Symptoms were ascites (74.3%), gastroi...
Epidemiology of hepatocellular carcinoma in areas of low hepatitis B and hepatitis C endemicity
Oncogene, 2006
Hepatocellular carcinoma (HCC) ranks among the 10 most common cancers worldwide. It evolves from several chronic liver diseases, most of which culminate in cirrhosis. As the most common causes, other than alcoholic cirrhosis, are chronic hepatitis B and C infections, its prevalence worldwide is linked to the prevalence of these two viruses. Thus, the highest rates are in southeast Asia and sub-Saharan Africa, the world's most populous nations, where hepatitis B virus infection is endemic. In most western countries, hepatitis C virus infection is the predominant cause, and hepatitis B-related liver cancer occurs largely among immigrants from countries of high hepatitis B endemicity. In most western countries, the incidence and mortality from HCC is increasing as a consequence of the chronic sequelae of the 'epidemic' of hepatitis C of the 1960-1980s. In the US, modeling of this infection predicts a continued rise in liver cancer over the next decade. Surveillance by the National Cancer Institute and the Centers for Disease Control confirms the increasing incidence of and mortality from HCC to the year 2000, although subsequent analyses suggest a slowing or possibly decline in the rate of increase. Whether this trend will continue requires further evaluation.
The purpose of this study was to develop an algorithm for identifying patients with chronic hepatitis B virus (HBV) using automated data sources from two US health systems and evaluate the algorithmÕs performance by quantifying the incidence of hepatocellular carcinoma (HCC) among chronic HBV patients. To allow comparisons with estimates from automated databases that may not contain all data elements used in this algorithm, we created three definitions of chronic HBV infection and used these definitions to create three overlapping cohorts. We compared the incidence of HCC in each cohort with the incidence of HCC in a matched general population comparison cohort with no evidence of HBV. Patients who met the most stringent criteria for chronic HBV infection (based on the standard definition of 6 months of infection using repeat laboratory tests and record review) were 146 times more likely to develop HCC than matched comparison patients (adjusted hazard ratio = 146.5, 95% CI: 74.0-289.8). Those not meeting the stringent criteria, but who met the criterion of at least one positive hepatitis B surface antigen test were 30 times more likely to develop HCC than comparison patients (adjusted hazard ratio = 29.8, 95% CI: 16.5-53.6). Finally, patients who met the criterion based on at least one HBV diagnosis were 38 times more likely to develop HCC than matched comparison patients (adjusted hazard ratio = 37.8, 95% CI: 25.9-55.1). The magnitude of the relative increase in HCC risk seen using different criteria used to define HBV infection indicate that these automated data algorithms can identify patients with chronic HBV infection.
BIRDEM Medical Journal
Background: Cirrhosis of liver is one of the important cause of liver disease in our country. Worldwide as well as in our country the most common cause of liver cirrhosis is due to hepatitis B virus (HBV) and hepatitis C virus (HCV) infection. Many of the patients with cirrhosis of liver do not know that they have already been affected with this kind of viral induced liver disease. They do not know how it occurs and what to be done afterwards due to lack of adequate knowledge with awareness and lack of proper guidance by the general physicians. The aim of our study is to see the demographic and virological profiles of cirrhosis of liver with their possible modes of transmission. Methods: This cross-sectional study was carried out during the period of July 2018 to June 2019 in Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM) General Hospital, Dhaka, Bangladesh. Cirrhosis of liver was diagnosed mostly with the help of ultrason...
Frequency of different Causes of Cirrhosis Liver in local population
Gomal Journal of Medical Sciences, 2012
Background: Cirrhosis liver is a common cause of morbidity and mortality in developing countries. The objective of this study was to find out the frequency of different causes of cirrhosis liver in patients admitted to medical unit. Material & Methods: A prospective study of 95 patients already diagnosed with cirrhosis liver or diagnosed as such during current admission was performed in the Medical B
Etiology of Hepatocellular Carcinoma and Association with Hepatitis B & C Virus
Pakistan Journal of Medical and Health Sciences, 2021
Aim: To evaluate the association of hepatitis with the hepatocellular carcinoma. Hepatitis is known as the inflammation of the liver. Methods: Hepatitis C and B may lead to HCC (hepatocellular carcinoma), such as Hepatitis B may cause 50% and hepatitis C is responsible for 70 to 80 % of cases of HCC. Obesity, alcohol and type 2 diabetes are also a predisposing factor for HCC. HCC is the malignant tumor, and have a low survival rate due to reoccurrence. Results: Eighty two patients were selected with hepatitis and HCC. This cross-sectional study was conducted at Allied Hospital Faisalabad. Ultrasound machine of Toshiba was used with a transducer of frequency 3-6MHz for the liver scanning. 82 patients with hepatitis B, C, and HCC were included in this study. Out of 82 patients, 55 were male and 27 were female. The mean age was 55yrs. Group A 45 (54%) patients were infected with hepatitis C and Group B 35(42%) patients were infected with hepatitis B. Hepatitis C is the most common caus...