Serine and 1-carbon metabolism are required for HIF-mediated protection against retinopathy of prematurity (original) (raw)

Retinopathy of prematurity (ROP) is a leading cause of vision impairment in infants, exacerbated by oxygen therapy necessary for survival. This research focuses on the role of hypoxia-inducible factor (HIF) in mediating metabolic responses to hypoxia, particularly its influence on serine and one-carbon metabolism. Stabilizing HIF through inhibition of its catabolism can enhance retinal protection against injury from hyperoxic conditions, suggesting that targeting these metabolic pathways may offer therapeutic strategies for preventing ROP.