Acute Generalized Exanthematous Pustulosis (AGEP) Triggered by a Spider Bite (original) (raw)
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IP Indian Journal of Clinical and Experimental Dermatology, 2023
Acute generalized exanthematous pustulosis (AGEP) or toxic pustuloderma is a febrile adverse cutaneous reaction, characterized by small non-follicular sterile pustules. AGEP can occur in any age group and is found to be more common in women. A large proportion (>90%) of cases are triggered by medications, particularly macrolides and aminopenicillins. The occurrence of AGEP following spider bite has been rarely documented in the literature.We report two cases who presented to us with AGEP following spider bite along with dermoscopic findings and also present a brief review of literature on the same. Keywords: Spider bite, Acute generalized exanthematous pustulosis, Erythema, Pustules, EuroSCAR, Dermoscopy, White globules
Berkala Ilmu Kesehatan Kulit dan Kelamin
Background: Pustular psoriasis and Acute Generalized Exanthematous Pustulosis (AGEP) are grouped under pustular diseases, in which their clinical manifestations are similar. Those diseases can lead to exfoliative dermatitis. Purpose:To evaluate a specific histopathological examination in differentiating Pustular Psoriasis and AGEP. Case: A 55-year-old woman presented with sudden redness and diffused scaly skin with multiple pustules and also fever. She had taken Cefadroxil 2 days before the scales and pustules appeared. Leukocytosis and histopathological examination results from biopsy supported the diagnosis of AGEP. The patient was then hospitalized and received steroid therapy. Within the first week of tapering off, the scales disappeared but the pustules increased. After such clinical findings, the histopathological examination results were revisited and reassessed. Thus, we considered changing the diagnosis to Pustular Psoriasis, and the therapy was switched to Methotrexate. Th...
Acute generalized exanthematous pustulosis (AGEP) - A clinical reaction pattern
Journal of Cutaneous Pathology, 2001
Background: A wide range of diseases or reactions can cause pustu-Alexis Sidoroff 1 , Sima Halevy 2 , lar eruptions of the skin. In this spectrum there seems to be a subgroup Jan Nico Bouwes Bavinck 3 , with characteristic clinical features and a typical course which is most-Loïc Vaillant 4 and ly caused by drugs for which the term acute generalized exanthema-Jean-Claude Roujeau 5 tous pustulosis (AGEP) has been established.
Acute generalized exanthematous pustulosis (AGEP): a literature review
Scripta Scientifica Medica, 2013
Acute generalized exanthematous pustulosis (AGEP) is a rare drug-induced pustular cutaneous reaction. The clinical course is characteristic with a sudden onset of multiple sterile pustules on an erythemantous base with fever and neutrophilia, followed by a spontaneous resolution within two weeks. Drug-specific T cells play the main role in the pathogenesis, but the exact cytokine cascade and genetic background are yet to be elucidated. Timely and exact recognition is important in order to prevent confusion with infections and psoriasis and hence institution of unnecessary and wrong treatments. The diagnosis may be confirmed by typical history, identification of a culprit drug, histopathology and patch testing. The purpose of this review is to present the current knowledge on AGEP and its association with various drugs in the context of a drug allergic reaction.
Acute Generalized Exanthematous Pustulosis; A Case Report
https://www.ijhsr.org/IJHSR\_Vol.12\_Issue.6\_June2022/IJHSR-Abstract.024.html, 2022
Introduction: Acute generalized exanthematous pustulosis (AGEP) is a severe allergic skin reaction associated with substance use. Not all drugs cause an AGEP reaction. The incidence of AGEP is extremely rare compared to other drug allergies. Therefore, correct identification and proper history acquisition are important for the purpose of providing appropriate and prompt treatment to patients, improving good prognosis and reducing mortality. Case Presentation: A 17 years antique male affected person, got here with leader proceedings of purple spots at the palms and ft observed with the aid of using itching. Red spots seem after the affected person takes the drug. The affected person became given remedy withinside the shape of oral antihistamines, intravenous steroids, and topical steroids. The affected person became discharged from the health center in excellent condition. Conclusion: Acute Generalized Exanthematous Pustulosis is a skin disorder that is generally caused by drugs and has a good prognosis because it can heal by itself.
Life-Threatening Dermatoses and Emergencies in Dermatology
JAMA, 2010
The justifi cation for addressing acute generalized exanthematous pustulosis (AGEP) in the context of life-threatening skin diseases is not so much due to a high mortality rate, but rather explained by three circumstances. Firstly, AGEP often has a quite drastic clinical appearance which, by its acute evolution,
The Man of a Thousand Pustules: A Case About Acute Generalized Exanthematous Pustulosis
Cureus, 2022
Acute generalized exanthematous pustulosis (AGEP) is a rare entity characterized by fever associated with the sudden appearance of erythematous lesions, on which multiple sterile, non-follicular pustules develop. We describe a case of a 44-year-old healthy male who developed fever and multiple erythematous and edematous lesions with progressive generalization to the entire body, associated with multiple small non-follicular pustules three days after having started flucloxacillin for the treatment of a furuncle. Considering the characteristics of the exanthema, fever, and association with aminopenicillin initiation, AGEP was considered. A skin biopsy revealed subcorneal and superficial epidermal pustules, with foci of spongiosis, papillary edema, and a superficial, perivascular inflammatory cell infiltrate with neutrophils and eosinophils, consistent with the clinical diagnosis of AGEP. The culprit drug was suspended, and prednisolone was started, considering the rash extension, with progressive and complete improvement. Although it is a rare condition, the hypothesis of AGEP should be considered in acute febrile conditions with disseminated pustules. It resolves spontaneously after discontinuation of the offending drug, and the diagnosis is based on clinical presentation and skin biopsy.
Inverse subcorneal pustular dermatosis
Journal of the European Academy of Dermatology and Venereology, 2003
is characterized by a chronic relapsing pustular eruption predominantly involving the flexures and trunk 2 in middleaged women. We report a case of SCPD in a young female which was present in an atypical distribution as it was localized solely to the extensors of distal extremities.