Rare Case of Frontal Bone Hematogenic Osteomyelitis, Complicated by Forehead Part Brain Abscess (original) (raw)
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Srpski arhiv za celokupno lekarstvo, 2002
Chronic inflammation of the middle ear is the most frequent cause of otogenic complications. Meningitis is the most frequent otogenic intracranial complication, followed by otogenic brain abscesses, while other complications are significantly less frequent. The study is aimed at presenting clinical casuistry of otogenic brain abscesses consequential to chronic suppurative otitis in order to evaluate modern diagnostic and therapeutic possibilities. The study was retrospective and included the patients treated at the Institute of Otorhinolaryngology and Maxillofacial Surgery of the Clinical Centre of Serbia diagnosed with otogenic brain abscess during a five-year period (1996-2000). A total of 9 patients (male to female ratio 8:1), aged 16-68 years, were assessed. The following parameters were analyzed: sex, age groups, place of living, occupation number of hospitalizations, diagnostic procedures, symptoms and clinical signs of otogenic complications, other otogenic complications asso...
Juvenis scientia, 2021
Одной из глобальных проблем в системе здравоохранения стала пандемия коронавирусной инфекции, вызванной вирусом SARS-CoV-2, и её многочисленные осложнения. COVID-19 был впервые зарегистрирован в Китае в городе Ухань в декабре 2019 года. Было установлено, что коронавирусная инфекция приводит к микрососудистым и макрососудистым осложнениям по всему организму. Последние данные указывают на тесную связь между тяжелыми клиническими проявлениями COVID-19 и повышенным риском тромбоэмболии. Это ассоциировано с несколькими факторами риска, такими как системное гипервоспаление, вызванное коронавирусной инфекцией, гипоксия и сопутствующие заболевания. Патофизиологические механизмы, лежащие в основе коагулопатии, связанной с COVID-19, состоят из таких компонентов, как диффузное повреждение эндотелиальных клеток, аномальная динамика кровотока и неконтролируемая активация тромбоцитов. Изучая ситуацию в период пандемии COVID-19 мы можем замечать, что у пациентов на фоне COVID-19 или же после него развиваются разные осложнения. В данной статье приведен клинический случай пациента с сахарным диабетом 2 типа, перенесшего тромбоз кавернозного синуса, осложненный остеомиелитом верхней челюсти после COVID-19. Ключевые слова: COVID-19, коронавирусная инфекция, тромбоз кавернозного синуса, остеомиелит верхней челюсти, сахарный диабет 2 типа, постинъекционный абсцесс. Конфликт интересов: Авторы заявляют об отсутствии конфликта интересов.
Terapevticheskii arkhiv, 2021
Acute disseminated encephalomyelitis (AEM) and acute transverse myelitis (OPM) are autoimmune demyelinating diseases of the central nervous system. Two clinical observations of AEM and OPM developed after suffering acute coronavirus infection (SARS-CoV-2) are presented. Differential diagnosis was carried out with multiple sclerosis, encephalitis of an infectious nature, compressive myelopathy, and opticomyelitis. Both observations show an almost complete recovery of lost functions. The pathogenetic mechanisms of the development of AEM and OPM in patients with coronavirus infection are discussed. The onset of central nervous system dysimmune lesion in the context of coronavirus infection makes it necessary to monitor the clinical situation with the involvement of a neurologist for timely diagnosis and determination of therapeutic tactics that can reduce the degree of disability of patients.
2021
BACKGROUND: Currently, the number of adolescents with terminal stages of coxarthrosis of various origins who underwent total hip joint arthroplasty has increased, as the use of modern implant models with a long service life has narrowed the age limit and expanded the indications for this intervention. AIM: This study aimed to assess the effectiveness of total hip arthroplasty in adolescents with stage 3 coxarthrosis caused by acute hematogenous osteomyelitis. MATERIALS AND METHODS: The study analyzed preoperative data and postoperative clinical, radiological, and functional examination data of 40 patients aged 1318 (15 1.2) years with stage 3 coxarthrosis caused by acute hematogenous osteomyelitis. The study group was composed of 21 (52.5%) boys and 19 (47.5%) girls. The control group consisted of 32 patients with stage 3 post-traumatic coxarthrosis, aged 1218 (15.4 1.7) years, of which 14 (43.75%) were girls and 18 (56.25%) were boys. RESULTS: The long-term functional results were ...
Feuillets de Radiologie, 2015
** Овај рад урађен је у оквиру пројекта Динамика структура српског језика, који финансира Министарство просвете, науке и технолошког развоја Републике Србије.
Successful treatment of recurrent unresectable squamous cell carcinoma of the head and neck using pembrolizumab, 2019
The study objective is to report a case of successful treatment of recurrent unresectable squamous cell carcinoma of the head and neck using pembrolizumab (selective inhibitor, preventing the interaction between the programmed death receptor 1 (PD1) and its ligands PD-L1 and PD-L2). Materials and methods. A 72-year-old male patient was admitted to the Clinic of Head and Neck Tumors, N.N. Blokhin Russian Cancer Research Center with the following diagnosis: primary metachronous malignant tumors: 1) oropharyngeal cancer T2N3M0 (after chemoradiotherapy, no relapse or metastases), 2) skin cancer of the left ear (T2N0M0, stage II, after combination treatment); relapse. After multiple surgeries for repeated relapses and external beam radiotherapy in March 2017, the patient was found to have new metastatic lesions in the retropharyngeal lymph nodes and paravertebral soft tissues of the neck (left side). The tumor was considered unresectable. The patient had high level of PD-L1 expression in the tumor (50 %), therefore, it was decided to initiate treatment with PD-1 inhibitors. The patient received pembrolizumab (keytruda) 200 mg once every three weeks (7 courses). Results. Positron emission tomography performed in February 2018 demonstrated no increased uptake of radiopharmaceutical in the retropharyngeal lymph nodes and paravertebral soft tissues of the neck, which were earlier affected. Since that time, the patient demonstrates sustained remission without any therapy. Conclusion. This case not only shows high efficacy of PD-1 inhibitors for aggressive recurrent head and neck squamous cell carcinoma, but also opens new opportunities for the treatment of weakened patients after chemotherapy and radiation exposure. Key words: head and neck tumors, squamous cell carcinoma, PD-1 inhibitors, immunotherapy, pembrolizumab For citation: Mudunov А.М., Gelfand I.М., Ryzhova О.D. et al. Successful treatment of recurrent unresectable squamous cell carcinoma of the head and neck using pembrolizumab. Opukholi golovy i shei = Head and Neck Tumors 2019;9(1):93–8