Cerebrospinal Fluid Biomarkers Predict Gait Outcomes in Idiopathic Normal Pressure Hydrocephalus (original) (raw)

ABSTRACTThe assessment of biomarkers in selecting idiopathic normal pressure hydrocephalus (iNPH) patients for shunt surgery has been limited to small cohort studies and those with limited follow-up. We assessed the potential for cerebrospinal fluid (CSF) biomarkers in predicting immediate response to CSF tap test (TT) and long-term response after shunt surgery.CSF was obtained from iNPH patients referred for CSF TT after baseline assessment of cognition and gait. CSF neurofilament-light (NFL), β-amyloid-42 (Aβ1-42), β-amyloid-40 (Aβ1-40), total tau (t-Tau), and phosphorylated-tau-181(pTau181) and leucine-rich-alpha-2-glycoprotein1 (LRG1) were measured by ELISA. The ability of these measures to predict immediate improvement following CSF TT and long-term improvement following shunt surgery was compared by univariate and adjusted multivariate regression.Lower NFL, pTau181, tTau and Aβ1-40 were individually predictive of long-term improvement in gait outcomes after shunt surgery. A mu...