Identification of a novel type of small molecule inhibitor against HIV-1 (original) (raw)
A small molecule HIV-1 inhibitor that targets the HIV-1 envelope and inhibits CD4 receptor binding
Nicholas Meanwell
Proceedings of the National Academy of Sciences, 2003
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Identification of an Antiretroviral Small Molecule That Appears To Be a Host-Targeting Inhibitor of HIV-1 Assembly
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Structure-Based Discovery and Characterization of a Preclinical Drug Candidate for the Treatment of HIV-1 Infection
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A novel small-molecule inhibitor of HIV-1 entry
Olga Latinovic
Drug Design, Development and Therapy, 2015
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Synthesis, antiviral activity and resistance of a novel small molecule HIV-1 entry inhibitor
Asim Kumar Debnath
Bioorganic & Medicinal Chemistry, 2015
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Discovery of a small-molecule antiviral targeting the HIV-1 matrix protein
Simon Cocklin
Bioorganic & Medicinal Chemistry Letters, 2013
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Synthesis, Biological Activity, and Crystal Structure of Potent Nonnucleoside Inhibitors of HIV-1 Reverse Transcriptase That Retain Activity against Mutant Forms of the Enzyme †
Kalyan Das
Journal of Medicinal Chemistry, 2007
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Discovery of small molecule HIV-1 integrase dimerization inhibitors
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Bioorganic & Medicinal Chemistry Letters, 2012
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Identification of small molecule modulators of HIV-1 Tat and Rev protein accumulation
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Discovery of a Potent HIV Integrase Inhibitor That Leads to a Prodrug with Significant anti-HIV Activity
Sanjay Mishra
ACS Medicinal Chemistry Letters, 2011
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A New Generation of Peptide-based Inhibitors Targeting HIV-1 Reverse Transcriptase Conformational Flexibility
Pascal Clayette
Journal of Biological Chemistry, 2009
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Identification of low-molecular weight inhibitors of HIV-1 reverse transcriptase using a cell-based high-throughput screening system
Miguel Quiñones-mateu
Antiviral Research, 2011
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Identification of mechanistically distinct inhibitors of HIV-1 reverse transcriptase through fragment screening
Gilda Tachedjian
Proceedings of the National Academy of Sciences of the United States of America, 2015
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Small-Molecule Inhibition of Human Immunodeficiency Virus Type 1 Replication by Specific Targeting of the Final Step of Virion Maturation
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Progress in HIV-1 Integrase Inhibitors: A Review of their Chemical Structure Diversity
zahra hajimahdi
Iranian journal of pharmaceutical research : IJPR, 2016
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Design, Synthesis, and Antiviral Evaluation of Chimeric Inhibitors of HIV Reverse Transcriptase
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ACS Medicinal Chemistry Letters, 2013
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New Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of Action
Roman Sakowicz
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HIV-1 integrase inhibitors: a review of their chemical development
Manish Bhatia
Antiviral Chemistry & Chemotherapy, 2011
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Discovery of 3-{5-[(6-Amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile (MK-4965): A Potent, Orally Bioavailable HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor with Improved Potency against Key Mutant Viruses
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Dimerization inhibitors of HIV1 reverse transcriptase, protease and integrase: A single mode of inhibition for the three HIV enzymes
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Identification of a 3-aminoimidazo[1,2-a]pyridine inhibitor of HIV-1 reverse transcriptase
John Young
Virology Journal, 2012
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Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor: A platform for antiviral drug design
Yehuda Goldgur
Proceedings of the National Academy of Sciences, 1999
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Fragment Based Strategies for Discovery of Novel HIV-1 Reverse Transcriptase and Integrase Inhibitors
Jennifer La
Current Topics in Medicinal Chemistry, 2015
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Structure and Function of HIV-1 Reverse Transcriptase: Molecular Mechanisms of Polymerization and Inhibition
Kalyan Das
Journal of Molecular Biology, 2009
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Discovery of a small-molecule HIV-1 integrase inhibitor-binding site
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Proceedings of the National Academy of Sciences, 2006
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Identification of benzofurano[3,2-d]pyrimidin-2-ones, a new series of HIV-1 nucleotide-competing reverse transcriptase inhibitors
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Bioorganic & Medicinal Chemistry Letters, 2013
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Progress in development of HIV-1 integrase inhibitor
Shikha Kaushik
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Crystal Structures for HIV-1 Reverse Transcriptase in Complexes with Three Pyridinone Derivatives: A New Class of Non-Nucleoside Inhibitors Effective against a Broad Range of Drug-Resistant Strains
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