Effects of Testosterone Administration on Fat Distribution, Insulin Sensitivity, and Atherosclerosis Progression (original) (raw)

The paper investigates the effects of testosterone administration on fat distribution, insulin sensitivity, and atherosclerosis progression, particularly in HIV-infected men suffering from fat redistribution syndrome. Despite common beliefs associating testosterone supplementation with increased cardiovascular risks, the authors present evidence showing physiological testosterone levels may reduce visceral fat, enhance insulin sensitivity, and potentially mitigate atherosclerosis. These findings emphasize the need for further randomized clinical trials to ascertain the long-term implications of testosterone therapy.