Brain Metastasis of Uterine Leiomyosarcoma: A Case Report and Review of the Literature (original) (raw)
Related papers
Cerebral Metastasis of a Uterine Leiomyosarcoma : Case Report
Neurologia Medico Chirurgica, 1999
A 38-year-old female presented with sudden neurological deterioration 6 years after an operation and chemotherapy for uterine leiomyosarcoma. An extremely rare metastasis of the uterine leiomyosarcoma to the brain was identified and totally resected. Whole brain irradiation (50 Gy) was given. A recurrence of the metastasis was resected 10 weeks later. She ultimately died of a second recurrence. Aggressive surgical management of cerebral metastasis of uterine leiomyosarcoma may achieve an improved outcome.
Cerebral Metastasis of a Uterine Leiomyosarcoma
Neurologia medico-chirurgica, 1999
A 38-year-old female presented with sudden neurological deterioration 6 years after an operation and chemotherapy for uterine leiomyosarcoma. An extremely rare metastasis of the uterine leiomyosarcoma to the brain was identified and totally resected. Whole brain irradiation (50 Gy) was given. A recurrence of the metastasis was resected 10 weeks later. She ultimately died of a second recurrence. Aggressive surgical management of cerebral metastasis of uterine leiomyosarcoma may achieve an improved outcome.
Leiomyosarcoma of the uterus metastatic to the brain: a case report
Archives of Gynecology and Obstetrics, 2009
Uterine leiomyosarcoma is a rare tumour with an aggressive growth pattern. The principle treatment is surgical excision by abdominal hysterectomy, however, the rate of recurrent disease is high. Radiotherapy and chemotherapy have limited impact on overall survival and the prognosis for those patients with recurrent disease is poor. Cerebral metastases are extremely uncommon with only 14 cases published in the literature. We report a further case who succumbed to systemic disease 2 months following successful excision of a solitary brain metastases. This case highlights the aggressive nature of the tumour and poor prognosis despite successful neurosurgical excision.
Brain and lung metastasis of uterine leiomyosarcoma: illustrative case
Journal of neurosurgery, 2023
BACKGROUND Uterine leiomyosarcoma is a rare, extremely aggressive tumor with a high rate of metastasis. Five-year survival for individuals with metastatic disease is only 10%-15%. Metastases to the brain are exceptionally rare and are associated with poor survival. OBSERVATIONS The authors report a case of uterine leiomyosarcoma that metastasized to the brain in a 51-year-old woman. A single lesion on magnetic resonance imaging was discovered in the right posterior temporo-occipital region 44 months after resection of the primary uterine tumor. The patient underwent a right occipital craniotomy with gross-total resection of the tumor and is receiving adjuvant stereotactic radiosurgery and chemotherapy with gemcitabine and docetaxel. At 8 months postresection, the patient remains alive and asymptomatic with no sign of recurrence. A literature review of prior reported cases was conducted to analyze patterns of approach to patient treatment and survival. LESSONS The authors found an apparent survival benefit in patients receiving adjuvant radiation therapy.
Uterine leiomyosarcoma is a rare malignancy with poor prognosis that occurs during pre-and peri-menopause. Metastatic spread in uterine leiomyosarcoma is common, but intradural spinal cord metastases is a very rare event, and, for this reason, there is no standard treatment. We report the case of a 58-years-old woman with onset symptoms related to intradural extramedullary metastasis and no gynecological signs. She underwent dorsal laminectomy followed by chemotherapy with gemcitabine and docetaxel and radiotherapy. Although she is suffering from a very serious illness, she is currently in good general condition. Some studies believe that the mutation of HRD and BRCA will be a therapeutic target in the future.
Primary leiomyosarcoma of the uterine cervix: an unusual case and critical appraisal
Journal of Surgical Case Reports
Leiomyosarcomas of the uterine cervix are rare, mostly occurring in perimenopausal women. Diagnosis is based on pathology and immunohistochemistry. Surgery with a total abdominal hysterectomy and bilateral salpingo-oophorectomy remains the standard. A female patient in her 60s presented with heavy postmenopausal bleeding. Vaginal ultrasound scan and magnetic resonance imaging showed a large strongly vascularized cervical mass with features suspicious of sarcomatous degeneration. Positron Emission Tomography-Computed Tomography (PET-CT) did not reveal any evidence of metastases nor lymphadenopathy, but presence of right hydronephrosis. An abdominal hysterectomy with bilateral salpingo-oophorectomy, and end-to-end anastomosis of the right ureter, was performed. Pathology showed an International Federation of Gynecology and Obstetrics (FIGO)-stage 1B leiomyosarcoma of the uterine cervix. No adjuvant treatment was given. Adjuvant radiotherapy reduces the risk of recurrence but no surviv...
Surgical Neurology International, 2013
Background: Uterine papillary serous adenocarcinoma (UPSAC) occurs 10-fold less frequently than endometrial carcinoma, and is referred to type 2 endometrial adenocarcinoma. The prognosis of UPSAC is worse than that of type I endometrial carcinoma. Herein we report what is only the second case of UPSAC, but it should prove to be more informative than the first reported case. Case Description: A 71-year-old female had three different metastases in the brain; two of the metastases were located in the posterior fossa within the cerebellar parenchyma with perilesional edema, but no mass effect, and the third metastasis was located in the right frontal lobe, and caused hemispheric edema and subfalcine herniation. The lesion that caused mass effect was completely extirpated without any surgical complications. The patient's recovery was excellent. She is able to walk independently, and use her left hand and left arm. Her Karnofsky performance score 5 months postsurgery was 80/100. Conclusion: Based on the outcome in the presented case, we think that in any UPSAC patient with a metastatic brain tumor causing mass effect the symptomatic metastatic tumor must be removed, regardless of disease grade, to ensure optimal quality of life.
Long survival in patients with metastatic leiomyosarcoma of the uterine corpus: A report of 2 cases
2010
and generally has a poor prognosis. A report of palliative treatment for invasive leiomyosarcoma of the uterine corpus with pulmonary metastases in 2 women is presented. Both patients presented with advanced bulky locoregional and metastatic disease. The patients had palliative care using multimodality approach with surgery, chemotherapy and radiotherapy. 2 years after treatment, the patients were alive without evidence of locoregional disease, with one patient having residual pulmonary metastasis. Despite evidence of metastasis, it is possible to have long survival, effective palliative care and improvement in quality of life with multimodality and multidisciplinary collaboration.
Brain metastasis from uterine serous carcinoma: A case report and review of literature
Gynecologic Oncology Reports, 2015
While endometrial cancer is the most common gynecological cancer with a generally favorable prognosis, the histological subtype of serous carcinoma is more aggressive and fortunately uncommon. Uterine serous carcinoma (USC) accounts for about 10% of cases of endometrial cancer and yet 39% of its deaths ). Brain metastasis from endometrial cancer is also rare, with a rate of 0.6% from a review of over 10,000 patients (Piura and Piura, 2012). This recent review of 35 studies by Piura et al. identified 115 cases of endometrial cancer that metastasized to the brain, of which 4 were USC (Piura and Piura, 2012). A further review of the literature uncovered an additional 4 cases. Here we present a new case from our institution, review the existing literature, and discuss current treatment options.