Application of Mycogenic Nanoparticles Against Neurodegenerative Diseases (original) (raw)

Nanobiotechnology in Neurodegenerative Diseases, 2019

Abstract

Metallic nanoparticles biosynthesis studies such as gold, silver, selenium, iron, metal oxides, and others, by microorganisms, especially fungi, have received great interest from the international scientific community because it is an ecological alternative. This chapter aims to evaluate recent advances in biosynthesis of fungal nanoparticles, with emphasis on physicochemical properties, bioactivity, and applications. Recent advances in biotechnology have provided interesting tools for the controlled synthesis of nanoparticles, using fungi as biotechnological factories. Due to the great diversity of polysaccharide enzymes and polysaccharide structures synthesized by fungi, it makes this kingdom very promising for the nanoparticles biosynthesis. The synthesized nanoparticles present different physicochemical properties, as they depend on biochemical parameters related to the biosynthesis process, besides the conditions used during the process, such as temperature, pH and substrate concentration. Metal nanoparticles associated with polysaccharides and proteins; depict bioactivity related to treatment of diseases such as neurodegenerative diseases. These nanoparticles are ecologically friendly and hence can be applied in medicine.

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