The multifaceted role of Notch in cancer (original) (raw)

Notch receptors play a critical role in both normal tissue development and cancer biology, acting variably as oncogenes or tumor suppressors depending on the cellular context. This review discusses the complex signaling mechanisms of Notch, illustrated by a detailed examination of recent studies revealing its various roles in cancer progression and differentiation. Understanding these multifaceted functions of Notch could inform potential therapeutic strategies targeted at modulating its pathways for cancer treatment.