Guanosine 3',5'-cyclic monophosphate and the in vitro physiology of frog photoreceptor membranes (original) (raw)

This research investigates the relationship between light-induced changes in cyclic GMP levels and the physiological responses of frog retinal rod outer segments in vitro. The study utilized a modified Ringer's solution to maintain the viability of outer segments during experiments and examined the effects of various compounds, including papaverine, on cyclic GMP degradation and permeability changes. Results indicate that light exposure decreases cyclic GMP levels, affecting the outer segments' swelling behavior in correlation with light intensity, thereby shedding light on the underlying biochemical mechanisms of phototransduction.