A study of Italian pediatric celiac disease patients confirms that the primary HLA association is to the DQ(α1∗0501, β1∗0201) heterodimer (original) (raw)
1992, Human Immunology
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Celiac disease (CD) has been recently reported to be primarily associated with the DQ(c~I*0501, /31"0201) heterodimer encoded in cis on DR3 haplotype and in trans in DR5,7 heterozygous individuals. The high incidence of DR5,7 heterozygotes, reflecting the high frequency of the DR5 allele in Italy, makes the analysis of the Italian CD patients critical.