Iss 2 Citation: Zeyede Aregahegn. Structural Study on Propylamide by FT-IR Spectrometry Using Chemometrics Applications (original) (raw)

Introduction The amide functionality is a common feature in small or complex synthetic or natural molecules existing everywhere in life [1]. The reactivity of amides is related to their structure and their tautomeric equilibria (SCHEME 1). Therefore, it can be useful to determine their spectral behavior in different conditions in order to study their tautomeric distribution [2]. Propylamide can form amide imidol tautomer [3,4]. Although enols are thermodynamically unstable species in comparison with their carbonyl isomers, some of them have a long enough lifetime so as to be detected by some instrumental methods [5,6]. R NH 2 O R NH OH SCHEME 1. Tautomeric equilibria of amides. Abstract Solvent effects and sample concentration effects on the structural changes of propylamide have been investigated by FT-IR measurement using principal component analysis. The absorption peaks observed at higher frequency and higher intensity when using chloroform and dichloromethane compared to benzen...