Variability of myostatin genes in rainbow trout (Oncorhynchus mykiss) strains exhibiting distinct hyperplastic growth: preliminary results (original) (raw)

The distinct growth capacities exhibited by slow-and fast-growing rainbow trout strains were associated with the potential to form new muscle fibres. The structural variability of myostatin genes (myostatin 1 and myostatin 2), negative regulator of muscle growth, was then investigated in trout red muscle. Myostatin cDNAs did not show any missense mutations in its coding sequence, in any of the analysed strains. However, several silent single nucleotide polymorphisms (SNP) were found in both myostatin genes. Other allelic polymorphisms, probably related to the existence of heterozygosity within strains, were also detected in myostatin 1. No sequence variability was found in the myostatin genes, in either of the two strains, which would obviously modify the functional properties of the corresponding proteins.