Evaluation of anti-inflammatory, analgesic, and antipyretic effects of ethanolic extract of Pedalium murex linn. fruits (original) (raw)
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Journal of ethnopharmacology, 2000
The study investigated the anti-nociceptive and anti-inflammatory properties of a Nigerian Polyherbal Health Tonic tea aqueous extract (PHT) in rodents of both sexes. 100 -500 mg kg -1 of the aqueous extract was administered via the intra-peritoneal (i.p.) and oral (p.o.) routes to 5 groups of mice using tail immersion, tail clip, formalin and acetic acid -induced writhing tests of experimental nociceptive models. Each of the models showed that PHT possesses a significant (p<0.05) anti-nociceptive effects which were peripherally and centrally mediated as both the early and late phases of pain significantly (p<0.05) were inhibited. However, the peripherally mediated analgesic effect of PHT, although similar to that of aspirin but was found to be more potent than aspirin. In assessing its anti-inflammatory potentials, 300 -1340 mg kg -1 PHT was also administered via oral and intraperitoneal routes, which, significantly (p<0.05) reduced the volume of carrageenan-induced oedema. Although, PHT administered via i.p. route was more effective than the oral but there was barely any difference between the percentage inhibition of oedema volume at both 600 and 1340 mg kg -1 given orally. PHT anti-inflammatory effect was elucidated to be significantly (p<0.05) mediated via histaminergic, serotonergic, bradykinin and prostaglandin inhibition. PHT was also shown to be more protective than acetylsalicylic acid (ASA) in the castor oil-induced diarrhea model, which suggests the involvement of other mechanisms. Thus, lending supports to its folkloric use in pain and swelling management.
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Medicinal plants with potential therapeutic activities are a tremendous resources of prospective drug candidates. NSAIDs, opiates, and other anti-inflammatory & analgesic agents exhibit several unwanted side-effects. Thus, the development of new active compounds with minimum adverse effects necessitates an emergence. This study aims to provide a comprehensive summary of plant species and reported phytoconstituents with analgesic and inti-inflammatory activities. Eighty-seven species from fifty-two plant families with reported constituents and activities have been included in this review. In-depth research in the area of screening novel analgesic and antiinflammatory agents from natural sources followed by the investigation of their pharmacological properties and clinical applications may lead to the generation of new active agents with better therapeutic activity and selectivity in the future. Dhaka Univ. J. Pharm. Sci. 19(2): 207-224, 2020 (December)
STUDY OF ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY OF MUSA SP Peels (Cavendish)
The various parts of banana, Musa acuminate, such petiol and peel is known to have medical benefits. Banana peels make up 40% of the fresh fruits and is a major agriculture waste. This research investigated the anti-inflammatory and analgesic activities of banana peels specifically the potential of Cavendish variety which is popularly consumed. In this study, two different doses, 200 mg/kg and 400 mg/kg of ethanolic peel extracts were given to the rats via oral administration. The analgesic activity was then evaluated by using Eddy's hot plate method to measure the latency time of the rats on the hot plate. As for anti-inflammatory study, the test were evaluated by measuring the inflammation induced subcutaneously by using 1% of 0.05 ml of formalin into the sub plantar region of on the left hind paw of the rats. The group and the results were expressed in " Mean ± SEM " as statistical identifiable value and p<0.05 were considered statistically significant. Hot plate test showed vast analgesic reaction in the extract of 400 mg/kg treated rats at the 60 th minutes which is comparable to positive control of diclofenac sodium. The anti-inflammatory test showed vast inflammatory action at the 6 th hour which is comparable to the positive control. Largest inhibition of inflammation was seen at the 6 th hour which was 63% in rats received 400mg/kg extract. These findings indicated that the Cavendish peel's exhibit analgesic and anti-inflammatory activities.
Anti-inflammatory, analgesic and antipyretic effects of the fruit pulp of Adansonia digitata
Fitoterapia, 1994
This study investigated the general acute, anti-inflammatory, analgesic and antipyretic effects of methanol extract of Lepidagathis anobrya Nees (Acanthaceae). Carrageenan-induced rat paw edema and croton oil-induced ear edema in rats were used for the evaluation of general acute anti-inflammatory effects. Acetic acid-induced writhing response and yeastinduced hyperpyrexia in mice were used to evaluate the analgesic and antipyretic activities respectively. The extract at doses of 10, 25, 50 and 100 mgkg-1 for carrageenan test and doses of 0.5 mg/ear for croton oil test induced a significant reduction (p < 0.001) of paw and ear edemas in rats. In the analgesic and antipyretic tests, the extract has shown a significant inhibition of writhes and hyperpyrexia with all the doses used when compared to the untreated control group. These results clearly show the anti-inflammatory, analgesic and antipyretic effects of the methanol extract of Lepidagathis anobrya and give the scientific basis for its traditional use. Further studies are needed to clarify the mechanism of action and the components responsible for these pharmacological effects.
In vitro anti-inflammatory activity of different parts of Pedalium murex (L.)
International Journal of Herbal Medicine, 2016
The aim of the present study, phytochemical and anti-inflammatory activities of different parts of hydro alcoholic extracts of Pedalium murex (L.). The maximum phytocompounds were present in hydro alcoholic extracts of leaf of P. murex when compared to stem and pod. In vitro anti-inflammatory activity was screened against human red blood cell (HRBC) membrane stabilization method. The maximum percentage of stabilization (82.10±2.93%) was observed in hydro alcoholic extract of leaf at higher concentration. In vitro protein denaturation was screened by using egg albumin method. The maximum amount of inhibition of protein denaturation was showed in hydro alcoholic extract of stem of P. murex. The above result showed that the hydro alcoholic extract of P. murex possess antiinflammatory activity. So future to find out the bioactive phytocompounds of plant extract of P. murex, which was used to design the drug for the treatment various type of inflammatory diseases.
Journal of Medicinal Food, 2014
Unripe fruit of Annona muricata Linn. (Annonaceae) (soursop) is used in traditional African medicine for the treatment of neuralgia, rheumatism, and arthritic pain. This study sought to investigate the analgesic and antiinflammatory effects of lyophilized fruit extract of Annona muricata (AM) in rodents. The analgesic activity was evaluated using the mouse writhing, formalin, and hot-plate tests while the anti-inflammatory action was investigated using the carrageenan-induced rat paw edema and xylene-induced ear edema tests. Pretreatment with AM (50, 100, and 200 mg/kg, p.o.) produced dose-dependent (P < .001) inhibition of writhes and formalin-induced pain in the late phase. AM and morphine produced time-course increase in pain threshold in hot-plate test. However, the analgesic effect elicited by AM was reversed (P < .05) by naloxone pretreatment. Similarly, the time-dependent increase in paw circumference induced by carrageenan was inhibited by AM treatment with peak effect (0.23-0.10 cm; P < .001, 200 mg/kg; 6 h), which was comparatively similar to that of diclofenac treated. Further, the xylene-induced ear edema was significantly reduced by AM (50 or 100 mg/kg) pretreatment; however, the anti-inflammatory effect elicited by AM was prevented by pretreatment of mice with N G-nitro-l-arginine (20 mg/kg, i.p., nitric-oxide synthase inhibitor) 15 min before AM (200 mg/kg, p.o.). The in vitro cyclooxygenase assay also showed that AM produced concentration-dependent inhibition of both cyclooxygenase (COX)-1 and COX-2 activity by 39.44%-0.05% and 55.71%-0.12%, respectively, at 100 lg/mL. In conclusion, A. muricata possesses analgesic effect through interaction with opioidergic pathway and anti-inflammatory property through inhibition of chemical mediators of inflammation.
Dietary Constituents as Novel Therapies for Pain
The Clinical Journal of Pain, 2004
The use of complementary and alternative medicine has dramatically increased in the United States. The effects of select dietary constituents in animal models and clinical pain states are reviewed. Specifically, the antinociceptive and analgesic properties of soybeans, sucrose, and tart cherries are discussed. The potential actions of dietary constituents as antiinflammatory and antioxidant agents are presented.
Evidence-Based Complementary and Alternative Medicine, 2013
Fruits ofPterodon pubescensBenth have been used traditionally for the treatment of rheumatism, sore throat, and respiratory disorders, and also as anti-inflammatory, analgesic, depurative, tonic, and hypoglycemic agent. The study was aimed at evaluating the anti-inflammatory activity of the hexane fraction of an ethanolic extract ofP. pubescensfruits. The oil fromP. pubescensfruits was extracted with ethanol and partitioned with hexane. The anti-inflammatory activity was measured with increasing doses of the hexane fraction (FHPp) by using a carrageenan-induced rat model of pleurisy and a rat model of complete Freund's adjuvant-induced arthritis by using an FHPp dose of 250 mg/kg for 21 days. Treatment with an FHPp resulted in anti-inflammatory activity in both models. The results of biochemical, hematological, and histological analyses indicated a significant decrease in glucose, cholesterol, and triglycerides levels (18.32%, 34.20%, and 41.70%, resp.) and reduction in the numb...
Analgesic and anti-inflammatory properties of leaf extract
Journal of Ethnopharmacology, 2005
The aqueous and methanol extracts from the dry bulbils of Dioscorea bulbifera L. var sativa (Dioscoreaceae)-evaluated orally at the doses of 300 and 600 mg/kg against pain induced by acetic acid, formalin, pressure and against inflammation induced by carrageenan, histamine, serotonin and formalin in mice and rats, showed a dose dependant inhibition of pain and inflammation with a maximum effect of 56.38%, 73.06% and 42.79% produced by the aqueous extract, respectively on pain induced by acetic acid, formalin and pressure while the methanol extract at the same dose respectively inhibited these models of pain by 62.70%, 84.54% and 47.70%. The oral administration of aqueous and methanol extracts caused significant anti-inflammatory activity on paw oedema induced by histamine, serotonin and formalin. The present results show that the bulbils of Dioscorea bulbifera var sativa possess potent analgesic and anti-inflammatory activities. These activities may results from the inhibition of inflammatory mediators such as histamine, serotonin and prostaglandins. Thus, the analgesic activity of the bulbils of Dioscorea bulbifera may be at least partially linked to its anti-inflammatory activity.
International Immunopharmacology, 2014
Fruits of the Litsea family of trees and shrubs contain biologically active compounds, some of which have been used as natural nutrients and flavoring agents in food. In this study, we identified novel anti-nociceptive effects of the 30% ethanol extract, the CH 2 Cl 2 fraction and the associated active components (Hamabiwalactone A and B) from Litsea japonica fruit by using in vivo peripheral and central nervous pain models. In addition, we compared the antiinflammatory effects of several fractions from L. japonica fruit extracts using lipopolysaccharide (LPS)-stimulated Raw264.7 cells. The CH 2 Cl 2 fraction of L. japonica fruit (LJM) had an optimal combination of anti-inflammatory effects and low cytotoxicity. Dose response studies were performed to determine the inhibitory effects of LJM on the pro-inflammatory enzymes, COX-2/PGE 2 and NO/iNOS, and pro-inflammatory cytokines, IL-1β, IL-6, and TNFα. Molecular profiling revealed that LJM exerts anti-inflammatory effects through inhibition of NF-κB and JNK/ p38 MAPK signaling in LPS-induced macrophages. This study suggests that CH 2 Cl 2 fraction of L. japonica fruit and its bioactive components are potential candidates as anti-inflammatory and analgesic agents (painkillers) for the treatment of inflammatory diseases.