Effects of a Dietary Supplement on the Incidence of Acute Respiratory Infections in Susceptible Adults: A Randomized Controlled Trial (original) (raw)
Related papers
Nutrition Journal, 2019
Acute respiratory infections (ARI), including the common cold causes significant morbidity and economical losses globally. Micronutrient deficiency may increase ARI incidence risk and its associated duration and severity among healthy adults, but evidence are inconclusive. This study aims to systematically review all observations on the association between single micronutrient deficiency and ARI incidence, duration and severity in healthy adults. Systematic literature searches were conducted in PubMed, Cochrane Library, Embase and Scopus databases. Eligible studies were assessed for the reporting and methodological quality. Adjusted summary statistics with their relevant 95% confidence intervals or interquartile ranges were extracted for the outcomes of interest. The literature search identified 423 unique studies. Of which, only eight studies were eligible and included in the final review. Only vitamin D deficiency (VDD) was observed among these eight studies. There were no eligibl...
Systematic Reviews in Pharmacy, 2021
The corona pandemic 2019 (CoViD-19) has encouraged social movement for the physical distancing and awareness for the use of natural products of medicinal plants for home remedies. Scientists are working to unravel the genetic makeup of corona virus i.e., the causative agent of CoViD-19 in order to find treatments for the infection. Until now, even medicine and vaccine have been formulated in order to help cure the disease. The primary objective of this article is to identify and analyse the published articles in the areas of complementary herbal plant application for antiviral and anti-inflammatory properties, ways to enhanced immunity, and to cure infectious symptoms. One of the paramount options including the use of herb-based medicinal derivatives have been proposed to cure infections with the positive outcome. Most of the established traditional medicinal systems like Traditional Chinese medicine and Ayurveda have recommended a list of several potent herbal and essential oils th...
International Journal of Basic & Clinical Pharmacology, 2021
Respiratory tract infections (RTIs) are highly prevalent and variable in nature, and are accountable for considerable morbidity and mortality. Acute respiratory tract infections (ARIs) are the third leading cause of death worldwide and the most common cause of antibiotic prescription among adults. It is common knowledge that inappropriate or overuse of antibiotics for RTIs is a crucial contributing factor with respect to the emergence of microbes that are resistant to the drug’s effects. Overuse of antibiotics and antibiotic resistance is a global issue that is becoming a serious concern. There is a growing need for novel approaches and adjuvant therapies for such infections, particularly in the setting of worsening antibacterial resistance. The strategy of supporting the immune system of the host in advance of infection exposure would decrease the number and severity of infections and thus decrease antibiotic use. Micronutrients have varied roles throughout every stage of the immun...
Trials, 2020
Objectives Primary Objective • To assess the efficacy of herbal extracts in boosting innate immunity of patients with COVID-19 infection. Secondary Objectives • To assess the efficacy of herbal extracts in restoring respiratory health • To assess the efficacy of Cap. IP in early recovery of patients and decline in viral load • To assess the safety of herbal extracts Trial design This is a single centre, randomized, 2-arm, parallel group, double blind, 1:1 ratio, controlled, exploratory trial with a study period of 30 days from the day of enrolment. Participants Patients attending the COVID treatment centre at Yashwantrao Chavan Memorial Hospital, Nehrunagar, Pimpri, Pune, India were screened for their participation in the study. Patients who were known COVID-19 positive (with positive RT-PCR), eligible and willing were enrolled in the study. Intervention and comparator The intervention in the trial has a background in ‘Ayurved’. Intervention Arm: Two capsules, Investigational Produc...
International Journal of Child Health and Nutrition, 2020
Context: Several decades of dietary research recommended the consumption of antioxidants and vitamins rich foods as a protective tool against a broad portfolio of diseases Aims: This study aims to test if oral supplementation of natural antioxidants and vitamins before the winter season, may reduce the occurrence of upper respiratory tract infection (URTI) in adolescents. Settings and Design: Natural antioxidants and vitamins supplements were given to 90 adolescents (45 males, and 45 females) from an orphanage against a placebo during three months in a double-blind fashion. Methods and Material: Saliva was collected before and after supplementation. The antioxidant activity of saliva was determined in vitro using electrolysis as a free radical generating system. Additionally, total antioxidant activity, glutathione and ascorbic acid levels in the saliva were evaluated before and after supplementation. The URTI frequency was recorded throughout the winter season (3 months). Statistical Analysis: All values were expressed as means ± SEM. Significance of the results was assessed using Student's t-test and Fisher's test Results: Data indicated that only five individuals from the group that received antioxidants and vitamins supplements manifested URTI while 14 adolescents from the non-supplemented group showed symptoms of URTI. Biochemical analysis revealed that the saliva in provenance from the supplemented group exhibited a higher capacity to scavenge free radicals compared to its capacity before supplementation. This supplementation also increased the total antioxidant activity and the levels of both ascorbic acid and glutathione in the saliva. Conclusions: We concluded that oral intake of antioxidants and vitamins protects against URTI through increased antioxidant activity.
The Indian journal of nutrition and dietetics, 2010
Childhood malnutrition remains a major public health problem worldwide and has been widely recognized as an important risk factor for child mortality. An estimated 2.8 million child deaths is reported each year in the nine low-income Asian countries including India. Attempts are currently underway to quantitatively estimate the extent to which all forms of childhood malnutrition - including deficits in protein and energy and the micrcnutrients namely iron, vitamin A, iodine and zinc contribute to these adverse outcomes. In recent years, nutrition and Immunology are increasingly becoming interrelated disciplines. Micronutrient deficiency is associated with an impairment of immune responses and increased susceptibility to infections like upper and lower respiratory tract infections (URI/LRI) and skin infections especially in children.