Microtubule Integrity Regulates Src-like and Extracellular Signal-regulated Kinase Activities in Human Pro-monocytic Cells. IMPORTANCE FOR INTERLEUKIN-1 PRODUCTION (original) (raw)

Microtubule integrity plays a critical role in the regulation of pro-inflammatory cytokine production, specifically interleukin-1 (IL-1), in human monocytic cells. Disruption of microtubules via colchicine leads to the activation of the ERK signaling pathway and Src-like kinases, which are essential for IL-1 synthesis. The findings provide essential insights into the cellular mechanisms underlying inflammatory responses and the interplay between cytoskeletal integrity and signal transduction pathways.