Nanostructured Lipid Carriers: A Promising Approach for Topical Drug Delivery System (original) (raw)
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NANOSTRUCTURED LIPID CARRIER (NLC) A MODERN APPROACH FOR TOPICAL DELIVERY: A REVIEW
Solid lipid nanoparticles (SLN) were developed at the beginning of the 1990s as an alternative carrier system to emulsions, liposomes and polymeric nanoparticles. The paper reviews advantages also potential limitations of SLN for the use in topical pharmaceutical formulations. Features discussed include stabilisation of incorporated compounds, controlled release, occlusivity, film formation on skin including in vivo effects on the skin. As a novel type of lipid nanoparticles with solid matrix, the nanostructured lipid carriers (NLC) are presented, the structural specialities described and improvements discussed, for example, increase in loading capacity, physical and chemical long-term stability, triggered release and potentially supersaturated topical formulations. For NLC, the technologies to produce the final topical formulation are described, especially the production of highly concentrated lipid nanoparticle dispersions. 30–80% lipid content.
Nanostructured Lipid Carriers: A Groundbreaking Approach for Transdermal Drug Delivery
Advanced Pharmaceutical Bulletin
Nanostructured lipid carriers (NLCs) are novel pharmaceutical formulations which are composed of physiological and biocompatible lipids, surfactants and co-surfactants. Over time, as a second generation lipid nanocarrier NLC has emerged as an alternative to first generation nanoparticles. This review article highlights the structure, composition, various formulation methodologies, and characterization of NLCs which are prerequisites in formulating a stable drug delivery system. NLCs hold an eminent potential in pharmaceuticals and cosmetics market because of extensive beneficial effects like skin hydration, occlusion, enhanced bioavailability, and skin targeting. This article aims to evoke an interest in the current state of art NLC by discussing their promising assistance in topical drug delivery system. The key attributes of NLC that make them a promising drug delivery system are ease of preparation, biocompatibility, the feasibility of scale up, non-toxicity, improved drug loadin...
Nanostructured lipid carriers: A potential use for skin drug delivery systems
Pharmacological Reports, 2019
Skin application of pharmaceutical products is one of the methods used for drug administration. The problem of limited drug penetration via topical application makes searching for safe drug carriers that will provide an expected therapeutic effect of utmost importance. Research into safe drug carriers began with liposome structures, paving the way for work with nanocarriers, which currently play a large role as drug vehicles. Nanostructured lipid carriers (NLC) consist of blended solid and liquid lipids (oils) dispersed in an aqueous solution containing a surfactant. These carriers have many advantages: good biocompatibility, low cytotoxicity, high drug content; they enhance a drug's stability and have many possibilities of application (oral, intravenous, pulmonary, ocular, dermal). The following article presents properties, methods of preparation and tests to assess the quality and toxicity of NLC. This analysis indicates the possibility of using NLC for dermal and transdermal drug application.
Nanostructured Lipid Carrier (NLC) -A Promising Drug Delivery for Transdermal Application
2020
Skin application of pharmaceutical products is one of the methods used for drug administration. The problem of limited drug penetration via topical application makes searching for safe drug carriers that will provide an expected therapeutic effect of utmost importance. Research into safe drug carriers began with liposome structures, paving the way for work with nanocarriers, which currently play a large role as drug vehicles. Nanostructured lipid carriers (NLC) consist of blended solid and liquid lipids (oils) dispersed in an aqueous solution containing a surfactant. These carriers have many advantages: good biocompatibility, low cytotoxicity, high drug Content,they enhance a drug’s stability and have many possibilities of application (oral, intravenous, pulmonary, ocular, dermal). The present study emphasize to evoke an interest in the current art of NLC by discussing the various parameter like need of NLC,types of lipid, drug used in various NLC formulation,characterization,skin o...
International Journal of Pharmaceutical Investigation, 2019
Nanoparticulate drug delivery systems have an advanced and modern approach over the traditional delivery system. This systematic review on nanoparticulate drug delivery containing lipid and focus on preparation, challenges and advancement of delivery of the drug via topical and transdermal route. The first era of lipid nanoparticles were SLN and have more sustaining action as well as suitable for the higher permeation of drug. The NLC is the second generation lipid nanoparticles developed to overcome the limitation associated with SLN i.e low drug loading capacity, polymorphism of solid lipid. Production of solid lipid nanoparticles and nanostructured lipid carriers are produced by a variety of technologies which explored in the current review. Lipid nanoparticle has various properties for topical use of cosmetics and other pharmaceutical formulation, i.e. controlled and sustained release of medicaments, Physical and chemical stability of active pharmaceutical ingredients, targeted release, film formation and enhancing penetration with the enhancement of skin hydration. Skin hydration plays a major role in the topical delivery of API as it hydrates the skin which leads to opening of pores of skin. Due to occlusion nature of lipid nanopar-ticles trans epidermal water loss decline which softening the skin. The use of biodegradable grade lipid makes it more suitable because it does not cause any toxicity as created by polymeric nanoformulations. Furthermore, a discussion about the benefit/risk ratio of a nanoparticulate system containing lipids also explored in this paper. The SLN and NLC are a "nanosafe" carrier for the delivery of active pharmaceutical via topical route.
NANOSTRUCTURED LIPID CARRIERS FOR TRANSDERMAL DRUG DELIVERY
International Journal of Applied Pharmaceutics, 2022
Transdermal drug delivery offers many advantages over oral delivery, such as avoiding first-pass metabolism, enhancing the bioavailability of poorly soluble drugs, and providing better patient compliance. However, only small lipophilic molecules can be delivered across the stratum corneum, the outermost layer of the skin. Unfortunately, the delivery of larger molecules remains a challenge. Nanostructured lipid carriers (NLCs) are second-generation lipid nanocarriers composed of biocompatible solid lipids, liquid lipids, surfactants, and co-surfactants. NLCs can be loaded with various classes of drugs, provide a controlled drug release profile, enhance drug stability, and be scaled up without needing organic solvents. This review article discusses the features, composition, formulation processes, and characterization of NLCs and their potential use in transdermal drug delivery.
C:Solid lipid nanoparticles: a prospective approach for topical drug delivery
Records of Pharmaceutical and Biomedical Sciences
Solid lipid nanoparticles (SLNs) are categorized as a novel generation of nanocarriers attracting huge attention as innovative colloidal carrier systems used for drug delivery as they integrate the advantages and avoid the disadvantages of other colloidal carries such as liposomes and polymeric nanoparticles. SLNs are biocompatible and biodegradable as they are made from physiological lipids, which decrease the danger of toxicity. Moreover, SLNs have been used as a possible attractive drugcarrier for topical drug delivery. These review discuses on many aspects of SLNs such as advantages disadvantages, method of preparation, SLNs and topical delivery and their therapeutic applications.
Nano-lipid Carriers for Topical Application: Current Scenario
Asian Journal of Pharmaceutics, 2016
Since the beginning of the 1990s the nano-lipid carriers (NLCs) have been attracting a growing interest from the pharmaceutical technology research groups worldwide. NLCs appeared as consumer products first on the cosmetic market. The article gives an overview of the cosmetic benefits including enhancement of chemical stability of actives, film formation, controlled occlusion, skin hydration, skin bioavailability, and physical stability of the lipid nanoparticles. Solid-lipid nanoparticle as topical formulations. List of the cosmetic products currently available in the market, and bioequivalence protocol, excipients, improvement of the benefit/risk ratio of the topical therapy is shown.
2020
Solid lipid nanoparticles (SLNs) are categorized as a novel generation of nanocarriers attracting huge attention as innovative colloidal carrier systems used for drug delivery as they integrate the advantages and avoid the disadvantages of other colloidal carries such as liposomes and polymeric nanoparticles. SLNs are biocompatible and biodegradable as they are made from physiological lipids, which decrease the danger of toxicity. Moreover, SLNs have been used as a possible attractive drugcarrier for topical drug delivery. These review discuses on many aspects of SLNs such as advantages disadvantages, method of preparation, SLNs and topical delivery and their therapeutic applications.
Journal of Pharmacy Research, 2013
Aims: The work is aimed to formulate aqueous nanodispersion of aceclofenac Nanostructured Lipid Carriers (NLC) by using modified hot sonication method and to prepare NLC based gel for topical delivery of aceclofenac. Methods: The lipids incorporated in the study were Compritol 888 ATO and Miglyol and the emulsifier/stabilizer used was Polysorbate 80. The formulations were optimized by using 3 factor, 3 levels, BoxeBehenken design. The independent variables were combination of lipids (% w/w), concentration of emulsifier (% w/v), lipid drug ratio and the response variables were particle size, percentage entrapment and drug release after 12 h. The formulations were also characterized for particle size, entrapment efficiency, drug loading and depression in melting point. Results: The DSC, FTIR analyses were performed to characterize the state of drug and lipid modification. Shape and surface morphology were determined by SEM which showed spherical shape of the formulations. Further the formulations were evaluated for in vitro drug permeability study, rheological properties, skin irritation, pharmacodynamic and stability studies. Conclusion: The pharmacodynamic characteristics of aceclofenac NLC gel with reference to the conventional gel were compared by using Carrageenan induced rat paw edema method. The study showed the promising and stable alternative form for the aceclofenac for topical application.