Epithelial Myoepithelial Carcinoma of the Submandibular Salivary Gland (original) (raw)
Related papers
Epithelial–myoepithelial carcinoma of the parotid gland
Auris Nasus Larynx, 2003
Background: Ultrasound (US), Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) are widely used in the clinical diagnosis of parotid gland tumors and their efficacy in identifying benign lesions is well documented. However, problems arise when facing some malignant lesions. Only few cases of salivary gland low grade malignant tumors have been previously reported in the literature complete with the radiological features.
Recurrent Epithelial–Myoepithelial Carcinoma of the Submandibular Gland
Otorhinolaryngology clinics : an international journal, 2024
Epithelial-myoepithelial carcinoma (EMC) is a rare low-grade malignant tumor of the salivary glands. It occurs mostly in the parotid gland and is classically characterized by bilayered duct-like structures in histological examination. Its differential diagnosis includes all primary salivary gland clear cells tumors, and metastasis from renal cell carcinoma. The complete surgical resection with adjacent lymph nodes dissection represents the recommended therapy to ovoid recurrence. In our case, we describe a 37-year-old woman who presented a local recurrence of a submandibular tumor. The clinical examination demonstrated a well-circumscribed submandibular nodule. A surgical excision was performed and the histological immunohistochemical examination confirmed the diagnosis of submandibular EMC. The patient received a radiotherapy treatment and remained disease-free.
International Seminars in Surgical Oncology Isso, 2007
Background: Ultrasound (US), Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) are widely used in the clinical diagnosis of parotid gland tumors and their efficacy in identifying benign lesions is well documented. However, problems arise when facing some malignant lesions. Only few cases of salivary gland low grade malignant tumors have been previously reported in the literature complete with the radiological features. Case presentation: We here describe a case of epithelial-myoepithelial carcinoma (EMC) of the parotid gland, a low grade malignant tumor, with spread to an intraparotid lymph node and with CT and MRI findings mimicking a benign lesion. Conclusion: All the images revealed sharply outlined profiles and a homogeneous enhancement of the nodule, suggesting a benign tumor and demonstrating that a radiological evaluation of the lesion alone may be unsatisfactory and misleading in the diagnosis of salivary gland tumours, especially in the case of low grade malignant tumors, such as EMC.
Epithelial-Myoepithelial Carcinoma of the Parotid
Acta Cytologica, 1999
Background: Ultrasound (US), Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) are widely used in the clinical diagnosis of parotid gland tumors and their efficacy in identifying benign lesions is well documented. However, problems arise when facing some malignant lesions. Only few cases of salivary gland low grade malignant tumors have been previously reported in the literature complete with the radiological features.
Epithelial myoepithelial carcinoma of parotid gland-a case report
Epithelial-Myoepithelial Carcinoma is a rare malignant salivary gland neoplasm. It is also known as adenomyoepithelioma. It accounts for less than 1% of all salivary gland neoplasms. This unusual salivary gland tumors is first described by Donath et al in 1972. This tumor occurs in sixth decade and beyond having a female predominance. Parotid gland is the most commonly involved followed by submandibular gland and palate. Herein we are presenting a rare case of Epithelial-myoepithelial carcinoma of parotid gland.
Epithelial-Myoepithelial carcinoma (EMC) of the salivary gland is a rare tumor representing 1% of all salivary gland neoplasm. Fine needle aspiration cytology (FNAC) is the best tool for preoperative diagnosis of salivary gland neoplasms. However there are only few documented case reports of preoperatively diagnosed cases of EMC in English literature. We present a third case of cytologically diagnosed EMC and highlight the fact that three dimensional clusters, acellular basement membrane material, prominent central nucleoli and attempted tubule formation are important pointers to the cytological diagnosis of EMC at cytology
A case of high-grade epithelial carcinoma arising in a low-grade epithelial-myoepithelial carcinoma of the parotid gland is described. The patient was a 52 year-old male who presented a parotideal lump of approximately 20 mm in diameter and underwent excisional surgery. Histologically a typical low-grade epithelial myoepithelial carcinoma was evidenced and, in its context, an area of 7 x 4 mm showing focal aspects of a high-grade adenocarcinoma. The immunohistochemical pattern of the ductal epithelial cells of the low-grade component was similar to that of the epithelial cells of the high-grade carcinoma. The Ki-67 labelling index of the epithelial-myoepithelial carcinoma was 5%, whereas that of the high-grade lesion was 30%. EGFR, p53 and HER-2 genes seem to play no role in the biological behaviour of the tumour, as well as p16CDKN2A, BRAF, NRAS and C-KIT genes studied with biomolecular methods in both the highgrade and low-grade components. No local recurrence occurred after surgery, but multiple bone, cutaneous and lung metastases were detected 10 months later. The patient died 19 months after diagnosis.
Epithelial-Myoepithelial Carcinoma of the Salivary Glands
Otolaryngology-Head and Neck Surgery, 2015
Objective. Epithelial-myoepithelial carcinoma (EMC) is a rare neoplasm of the salivary glands. In this study, we aim to examine the demographic, clinicopathologic, and survival features of EMC using a population-based approach. Study Design and Setting. Retrospective cohort study. Subjects and Methods. The Surveillance, Epidemiology, and End Result (SEER) database (1973-2010) was queried for EMC of the major salivary glands. Data were analyzed with respect to various demographic and clinicopathologic factors. Survival was analyzed using the Kaplan-Meier and Cox proportional hazards models. Results. In total, 246 cases were available for frequency analysis and 207 for survival analysis. Mean 6 SD age at diagnosis was 63.8 6 15.4 years. EMC affected females more frequently (57.3%). Distant metastases were present at diagnosis in only 4.5% of cases. Overall disease-specific survival (DSS) at 60, 120, and 180 months was 91.3%, 90.2%, and 80.7%, respectively. Patients with low-grade histology had significantly better survival at 180 months relative to those with high-grade tumors (90.6% vs 0.0%, P = .0246). When stratified by tumor size, patients with lesions .4 cm had the worst survival at 180 months (58.8%, P = .0003). All but 9 of the 207 cases available for survival analysis underwent surgery. A total of 85 patients (41.1%) received radiotherapy in addition to surgery. No survival benefit was noted for patients who received radiotherapy compared with those who did not (P = .4832). Conclusion. This report represents the largest series of EMC to date. Despite being regarded as a low-grade, indolent tumor, a significant fraction of our cohort underwent radiotherapy in addition to surgery, with no apparent added survival benefit.
Misinterpreted Myoepithelial Carcinoma of Salivary Gland
American Journal of Surgical Pathology, 2019
Myoepithelial carcinoma (MECA) is an underrecognized challenging entity with a broad morphologic spectrum. Misinterpreting MECA is not uncommon as distinguishing it from its mimics, especially cellular myoepithelial-rich pleomorphic adenoma (PA), can be difficult. We described 21 histologically challenging cases of MECAs (16 MECA ex-PA and 5 MECA de novo). All MECAs ex-PA were intracapsular or minimally invasive except for 3 cases. Eighteen (86%) were initially misinterpreted as benign neoplasms, including PA (10), atypical PA (5), and myoepithelioma (3). The remaining 3 were initially diagnosed as malignant (MECA ex-PA) but were histologically challenging. Histologic features that were found most helpful in recognizing the malignant nature of MECA included: uniformly cellular myoepithelial proliferation with an expansile nodular lobulated pattern (all cases) and alternate hypocellular and hypercellular zonal distribution (76% of cases). Among the 16 MECA patients with follow-up, 14...
Myoepithelial carcinoma of the parotid gland
Collegium antropologicum, 2010
Rare malignant tumor of the salivary gland, a myoepithelial carcinoma, arose de novo in the right parotid gland. The initial tumor was composed predominantly of myoepithelial cells. Subsequently the tumor recurred three times, with infiltration of the bones of the cranial base. Histological examination showed sarcomatoid neoplasm composed of malignant spindle cells with high mitotic rate and perineural invasion. There was no involvement of cervical lymph nodes. Immunohistochemistry demonstrated myoepithelial differentiation: tumor cells were positively stained with vimentin, alpha smooth muscle actin and S-100 protein antibodies, and focal positively was noticed with cytokeratin (AE1/AE3) antibody. Large number of tumor cells nuclei was reactive with the monoclonal anti-p63 antibody, clone 4A4. Myoepithelial carcinomas exhibit a wide spectrum of morphological heterogeneity and for that reason could be confused with many tumors. Cytoarchitectural patterns and immunohistochemical prof...