Polyethylene glycol-400 Prompted An Efficient Synthesis of Thienyl Pyrazolo[1,5‐a] pyrimidines as Microbial Inhibitors (original) (raw)

Current Organic Synthesis, 2022

Abstract

Aim: The aim of this present work was to design and establish an efficient synthesis of new thienyl pyrazolo[1,5‐a] pyrimidines using enviormental friendly reaction solvent. Further, the newly synthesized compounds were evaluated for antimicrobial activity. Materials and Method: A series of thienyl pyrazolo[1,5‐a] pyrimidines have been synthesized by the condensation reaction of 4‐(4’‐chloro‐phenylazo)‐5‐amino pyrazole with α, β‐ unsaturated carbonyl composites (chalcones) using NaOH in polyethylene glycol-400 as green reaction solvent. The dissemination technique recommended by the National Clinical Laboratory Standards Committee was used to study the antimicrobial activities of synthesized compounds. Results and Discussion: Polyethylene glycol-400 prompted an efficient synthesis of thienyl pyrazolo[1,5‐a] pyrimidines has been discussed. By using PEG‐400 as green reaction solvent, excellent yields of the proucts were obtained in shorter reaction reaction time. Reaction solvent was ...

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