Exploring optical spectroscopic techniques and nanomaterials for virus detection (original) (raw)

Viral infections present significant global health challenges, highlighted by diseases such as COVID-19 and HIV. This study demonstrates a proof of concept for the detection of HIV-1 pseudoviruses using anti-HIV-1 gp41 antibodies immobilized on glass substrates. The conjugation of these antibodies with selenium nanoparticles and gold nanoclusters was characterized through various spectroscopic techniques. The results indicate successful biomolecular interactions and highlight the potential of this method for improving rapid and sensitive diagnostic capabilities for HIV.