Physical exercise modulates the homeostasis of human regulatory T cells (original) (raw)

Regular physical activity (PA) is known to enhance health and mitigate the risk of chronic diseases, but the biological mechanisms remain unclear. This study examines how PA influences the homeostasis of regulatory T (Treg) cells, crucial for immune regulation. An analysis of 245 elite athletes revealed that higher levels of cardiovascular fitness (measured by relVO2 peak) correlate with increased frequencies of Treg cells compared to age- and sex-matched controls. Notably, female athletes exhibited lower Treg cell frequencies than their male counterparts, indicating potential hormonal effects on Treg cell homeostasis.