Dynamin−SNARE interactions control trans-SNARE formation in intracellular membrane fusion (original) (raw)

Dynamin is known primarily for its role in membrane fission, yet this study unveils its significant involvement in membrane fusion processes as well. Specifically, the yeast dynamin homologue Vps1 was found to control the formation of trans-SNARE complexes essential for membrane fusion by interacting with specific SNARE proteins. This research reveals that Vps1 facilitates the generation of a pool of active Q a SNARE-tethering complexes, which underscores its dual regulatory role in both fission and fusion of intracellular organelles.