Evaluation of the Psychometric Properties of the Health Assessment Questionnaire (HAQ) in a Population of Individuals With Multiple Sclerosis (original) (raw)
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Health Problems Questionnaire in Multiple Sclerosis Patients: Development and Validation
2021
Background Multiple sclerosis patients are faced with numerous problems during their illness. Development of a self-report measure of health problems in multiple sclerosis patients is required based on cultural factors, `which can advance our understanding of the level of health problems for care planning and improvement of coping and quality of life. The current study aimed to develop and validate the scale of health problems of Multiple Sclerosis. Methods This present study is an exploratory sequential mixed method study that was conducted in three phases. In the first phase, the concept of health problems in MS patients was defined using the content analysis approach. In the second phase, the item pool was generated from findings of the first phase. In the third phase, psychometric properties of the scale were evaluated including face, content and construct validity as well as reliability. Results After examining the psychometric properties of validity and reliability, 33 items w...
A health-related quality of life questionnaire for multiple sclerosis Patients
Acta Neurologica Scandinavica, 2009
Objective - The construction of a brief, valid and reliable HRQoL questionnaire for use in multiple sclerosis patients based on generic and disease-specific HRQoL measures. Material and methods - The Medical Outcomes Study 36-item Short Form Health Survey (SF-36), COOP/WONCA Charts, and Disability & Impact Profile (DIP) were used in a longitudinal study in 162 patients with multiple sclerosis. Results - Factor analyses identified 2 underlying dimensions of HRQoL, relating to “physical functioning” and “psychological functioning”. Selection of the 3 highest loading reliable scales on each factor resulted in a final questionnaire consisting of 3 scales of the SF-36 and 3 scales of the DIP. In total 40 items were selected; completion time is about 10 min. Conclusion - The final questionnaire adequately measured 2 dimensions of HRQoL. The length of the questionnaire is acceptable for patients with MS in view of respondent burden.
Multiple Sclerosis Journal, 2003
The selection of measures of quality of life used in clinical trials of multiple sclerosis (MS) should be evidence-based. Head-to -head comparison of measures facilitates the selection of measures. The aim of the study was to compare the psychometric properties of the physical and psychological dimensions in three measures of quality of life to aid choice of the most appropriate scale for use in clinical trials of MS. O ne hundred and twenty-one people with MS (rehabilitation =57; steroids =64) completed a selection of health measures before and after treatment. The psychometric properties of three measures of physical function (MSIS-29 physical, SF-36 physical functioning, FA MS mobility) and three measures of psychological function (MSIS-29 psychological, SF-36 mental health, FA MS emotional well-being) were compared by examining data quality, scaling assumptions, acceptability, reliability, validity and responsiveness. Physical (0.63- 0.71) and psychological (0.70-0.75) scales we...
Quality of life assessment in patients with multiple sclerosis
Vojnosanitetski pregled, 2009
Multiple sclerosis (MS) is a chronic inflammatory disease of central nervous system. The main physiopatological feature of MS is demyelination. Multiple sclerosis is one of three most common causes of severe disability in youngest people. In patients with MS, apart from complete psychophysical status and objective neurologic status, a subjective perception of symptoms and signs, known as quality of life, must be considered, too. The aim of this study was to estimate a health related quality of life (HRQoL) in patients with multiple sclerosis (MS) and to investigate the correlations between scores of HRQoL and selected demographic and clinical parameters. A cross-sectional study was performed in patients meeting following inclusion criteria: MS diagnosis (McDonald's criteria), age 18-60 years, the Expanded Disability Status Scale (EDSS) < 8, and written informed consent. Exclusion criteria were exacerbation of MS in the last month, any preexisting major chronic illness and/or psychiatric disorders and antidepressive and/or corticosteroid therapy in the last month. The quality of life was measured by a disease specific instrument, MSQoL-54 (The Multiple Sclerosis Quality of Life). The neurological impairment was assessed using the Expended Disability Status Scale (EDSS) and Mini Mental Scale (MMS). The presence and severity of depression was estimated by the Hamilton Depression Rating Scale (HDRS). The presence and severity of fatigue was assessed by the Fatigue Severity Scale (FSS). Statistical analysis included descriptive statistics and correlation analysis. The higher HRQoL score was registered for mental health (56.3 +/- 19.5) than for physical one (51.3 +/- 17.9), which means that physical disability had more important influence on quality of life deterioration comparing to mental health. The highest values of HRQoL were observed in domains of Cognitive Functioning (77.4 +/- 22.5) and Pain (75.7 +/- 25.5). The lowest scores of HRQoL were registered in domains of Role Limitations due to Physical Problems (32.5 +/- 42.0) and Role Limitations due to Emotional Problems (44.6 +/- 47.8). HRQoL scores statistically significantly correlated with natural history of MS, duration of diseases, employment and marriage status of participants. Deterioration in quality of life scores in the most of MSQoL-54 scales and subscales statistically significantly correlated with the presence and severity of physical disability, depression status and fatigue in patients with MS. This study showed that different demographic and clinical parameters had a major influence on HRQoL impairment in the sample of patients with MS.
Background: Individual factors in multiple sclerosis (MS) patients may modify the reliability of health-related quality of life (HRQOL) assessment. Knowledge of these effects may enable physicians to identify patients at risk for poor perceived health. Objective: To investigatewhat individual factors may interactwithMS symptoms and their severity tomodify the reliability of HRQOL assessment; to explore the predictive values of the significant variables identified. Methods: HRQOL was assessed in 57 patients by the 36-Item Short Form Health Survey (SF-36). The Physical Component Summary andMental Component Summarywere dichotomized and applied as dependent variables for logistic regression analysis. The Functional Independence Measure (FIM), Expanded Disability Status Scale (EDSS), Fatigue Severity Scale (FSS), Cognitive Behavioral Assessment (CBA) and specific individual factors were tested as independent variables. Two-way contingency tables were used to calculate the predictive values. Results: Unemployment, smoking, and night waking were the most significant individual factors. Introversion, physical pain and difficulty falling asleep were also significant. EDSS-total ≥2, EDSS-pyramidal ≥2, FIM ≤123, FSS ≥5, depressive manifestations and bowel/bladder dysfunction were significant MS-related determinants. Sensitivity and specificity differed widely for each variable. Conclusions: Individual factors have relevance in HRQOL assessment. Their identification may help physicians construct the patient's risk profile. Sensitivity and specificity add weight to the significance of variables.
The development and validation of the Impact of Multiple Sclerosis Scale and the Symptoms of Multiple Sclerosis Scale. Objective: To develop and validate the Impact of Multiple Sclerosis Scale (IMSS) and the Symptoms of Multiple Sclerosis Scale (SMSS) using the Extended Disability Status Scale (EDSS) for construct validity. Design: Panel design involving test-retest over 4 months. Setting: A mailed survey. Participants: Volunteers with a diagnosis of multiple sclerosis (MS) recruited from an MS support service in Australia: 193 people (mean age, 39y) and 150 people participated at time 1 and time 2, respectively. Main Outcome Measures: Principal components analyses, the Cronbach alphas and descriptive statistics for the 2 scales; correlations for construct validity with the EDSS and retest; and confirmatory factor analysis to test the stability of IMSS and SMSS components over time. Results: The IMSS yielded 5 independent and reliable components; the SMSS yielded 3 components; both component structures were stable over time. These scales showed convergent validity with the EDSS. Conclusions: The IMSS and SMSS are psychometrically sound scales suitable for clinical and research purposes to assess the symptoms and impact of MS.
2008
Purpose. The aim of this study was to develop and test the structure of the Multiple Sclerosis Impact Profile (MSIP), and to evaluate its reliability and validity within a large group of MS patients. Method. Data were obtained from a postal survey of 377 patients attending the Groningen MS centre of the university hospital and 153 patients from the MS patients' association. Results. Factor analysis showed that the MSIP comprised domains representing the four components of the International Classification (ICF). The body functions component comprised two factors, which we divided into three scales: ‘muscles and muscle movement functions’ (MMF), ‘excretion and reproductive functions’ (ERF) and ‘mental functions’ (MF). The activities component comprised one factor, which we divided into two scales: ‘basic movement functions’ (BMF) and ‘activities of daily living’ (ADL). The participation component comprised one factor: ‘participation in life situations’ (PLS). The environmental fac...
Perceptions of Health and Relationships to Disability Measures among People with Multiple Sclerosis
International journal of MS care, 2009
Researchers use various measures to assess health status, impairment, functional limitations, and disability among people with Multiple Sclerosis. However, conceptually and empirically relationships among measures are not always clear. The purpose of this study was to examine the relationships among measures of impairment, disability, functional status and health related outcomes within a sample of 443 individuals with MS. A secondary purpose was to compare the reported health status of this sample to the health status of a population-based sample of individuals with and without disabilities. While both the MS sample and a population-based sample of individuals with activities limitations indicated poorer health than did their non-disabled counterparts, the MS sample reported more days in the past month when physical and mental health was not good and more days when poor health kept them from usual activities than the population-based sample of individuals with disabilities. Most me...