Functionalized Nanostructures for Transdermal Delivery of Drug Cargos (original) (raw)

Journal of drug targeting, 2017

Abstract

Nanotechnology has burgeoned over last decade exploring varieties of novel applications in all areas of science and technology. Utilization of bio-friendly polymers for engineering nanostructures (NS) improves safety and efficacy in drug delivery. Biopolymers not merely employed for fabricating drug carriers but also leveraged for surface functionalization of other NS to impart bio-mimicking properties. Biopolymer functionalized NS garnered researcher's attention because of their potential to enhance skin permeability of drug cargo. Biopolymers i.e. cell penetrating peptides (CPP), chitosan and hyaluronic acid (HA) not only enhances skin permeability but also add multiple functions due to their intrinsic biomimetic properties. This multifunctional drug delivery system is a promising tool to achieve skin delivery of large number of therapeutic agents. In this review, functionalization of NS with biopolymers particularly polysaccharides and polypeptides is discussed in detail. In ...

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