Carbon quantum dots: recent progresses on synthesis, surface modification and applications (original) (raw)
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Carbon Quantum Dots: Synthesis, Characterization and Biomedical Applications
The Turkish Journal of Pharmaceutical Sciences
KKN, ayırt edici özellik olarak, 10 nm'den daha küçük boyutu olan, küçük karbon nanopartiküllerdir ve izlenebilir hedeflenmiş salım, biyomedikal araştırma ve farklı terapi uygulamaları için zorunlu bir araç haline gelmiştir. Bu çalışmanın amacı, KKN'nın sentezi, karakterizasyon teknikleri ve biyomedikal uygulamaları ile ilgili güncel literatürü bir araya getirmekti. KKN sentezi için iki tip yapay yöntem yani yukarıdan aşağıya yaklaşım ve aşağıdan yukarıya yaklaşım kullanıldı. Yukarıdan aşağıya doğru yaklaşım, ark boşaltma yöntemini, lazer ablasyon yöntemini ve elektrokimyasal yöntemi içermektedir. Öte yandan aşağıdan yukarı yaklaşım, termal yöntem, mikrodalga destekli yöntem, hidrotermal ve sulu yöntem ve kalıp yöntemini içerir. Bu derlemede, CQD'nin biyomedikal alanda son dönemdeki ilerlemesini, sentetik yöntemlerine, karakterizasyonuna ve farklı uygulamalara odaklanarak açıkladık. Karbon noktaları, in vivo ve in vitro biyolojik görüntüleme ve etken madde salım çalışmaları için kapsamlı yeterliliğe sahiptir. Karbon noktaları için daha fazla sitotoksisite araştırması yapılmasına ihtiyaç duyulmasına rağmen, önceki veriler etken madde salımı ve biyolojik görüntüleme çalışmalarında karbon noktalarının parlak geleceğini göstermektedir. Anahtar kelimeler: Karbon kuantum noktalar, nanopartiküller, kuantum verimi, karbon nokta, fotolüminesans, nanokompozitler CQD are small carbon nanoparticles smallerl than 10 nm comprising distinctive properties, which have become an obligatory tool for traceable targeted delivery, biomedical research, and different therapy applications. The objective of the present work was to consolidate the current literature on the synthesis, characterization techniques, and biomedical applications of CQD. Two types of synthetic methods viz. top-down approach and bottom-up approach were used for the synthesis of CQD. The top-down approach includes the arc-discharge method, laser ablation method, and electrochemical method. The bottom-up approach includes the thermal method, microwave-assisted method, hydrothermal and aqueous method, and the template method. In this review, we explain the recent progress of CQD in the biomedical field, focusing on their synthetic methods and characterization, followed by different applications. Carbon dots have extensive adequacy for in vivo and in vitro bioimaging and drug delivery studies. Although more cytotoxicity studies of carbon dots are needed, the data above suggest a bright future for carbon dots in drug delivery and bioimaging studies.
Recent Developments in Carbon Quantum Dots: Properties, Fabrication Techniques, and Bio-Applications
2021
Carbon dots have gained tremendous interest attributable to their unique features. Two approaches are involved in the fabrication of quantum dots (Top-down and Bottom-up). Most of the synthesis methods are usually multistep, required harsh conditions, and costly carbon sources that may have a toxic effect, therefore green synthesis is more preferable. Herein, the current review presents the green synthesis of carbon quantum dots (CQDs) and graphene quantum dots (GQDs) that having a wide range of potential applications in bio-sensing, cellular imaging, and drug delivery. However, some drawbacks and limitations are still unclear. Other biomedical and biotechnological applications are also highlighted.
Carbon Quantum Dots for Biomedical Applications: Review and Analysis
Frontiers in Materials, 2021
Carbon quantum dots (CQDs) are a new type of nano-carbons that are currently favored over semiconductor quantum dots (QDs) because of their solubility, low toxicity, eco-friendliness, and cheap and facile synthesis giving desired optical characteristics. Moreover, their physiochemical properties can be controlled by their synthetic route. CQDs can emit fluorescence in the range from the UV to the near-infrared (NIR) region, making them suitable for biomedical applications. Fluorescence in these nano-carbon atoms can be tuned by varying the excitation wavelength. As of now, CQDs have been used in various applications such as in bioimaging, biosensing, electrochemical biosensing, drug delivery, gene delivery, photodynamic therapy in the treatment of cancers, pharmaceutical formulations, and treating inflammation. This article highlights the current progress and advancement of CQDs with focus on their synthetic routes, chemical and optical properties, and biomedical applications along ...
The advanced role of carbon quantum dots in nanomedical applications
Biosensors and Bioelectronics, 2019
Carbon quantum dots (CQDs) have emerged as a potential material in the diverse fields of biomedical applications due to their numerous advantageous properties including fluorescence, water solubility, biocompatibility, low toxicity, small size and ease of modification, inexpensive scale-up production, and versatile conjugation with other nanoparticles. Thus, CQDs became a preferable choice in various biomedical applications such as nanocarriers for drugs, therapeutic genes, photosensitizers, and antibacterial molecules. Further, their potentials have also been verified in multifunctional diagnostic platforms, cellular and bacterial bio-imaging, development of theranostic nanomedicine, etc. This review provides a concise in sight into the progress and evolution in the field of CQD research with respect to methods/materials available in bio-imaging, theranostics, cancer/gene therapy, diagnostics, etc. Further, our discussion is extended to explore the role of CQDs innanomedicine, which is considered to be the future of biomedicine. This study will thus help biomedical researchers in tapping the potential of CQDs to overcome various existing technological challenges.
Nanomaterials
Carbon dots (CDs) are usually smaller than 10 nm in size, and are meticulously formulated and recently introduced nanomaterials, among the other types of carbon-based nanomaterials. They have gained significant attention and an incredible interest in the field of nanotechnology and biomedical science, which is merely due to their considerable and exclusive attributes; including their enhanced electron transferability, photobleaching and photo-blinking effects, high photoluminescent quantum yield, fluorescence property, resistance to photo-decomposition, increased electrocatalytic activity, good aqueous solubility, excellent biocompatibility, long-term chemical stability, cost-effectiveness, negligible toxicity, and acquaintance of large effective surface area-to-volume ratio. CDs can be readily functionalized owing to the abundant functional groups on their surfaces, and they also exhibit remarkable sensing features such as specific, selective, and multiplex detectability. In additi...
Carbon “quantum” dots for bioapplications
Experimental Biology and Medicine, 2021
Carbon “quantum” dots or carbon dots (CDots) exploit and enhance the intrinsic photoexcited state properties and processes of small carbon nanoparticles via effective nanoparticle surface passivation by chemical functionalization with organic species. The optical properties and photoinduced redox characteristics of CDots are competitive to those of established conventional semiconductor quantum dots and also fullerenes and other carbon nanomaterials. Highlighted here are major advances in the exploration of CDots for their serving as high-performance yet nontoxic fluorescence probes for one- and multi-photon bioimaging in vitro and in vivo, and for their uniquely potent antimicrobial function to inactivate effectively and efficiently some of the toughest bacterial pathogens and viruses under visible/natural or ambient light conditions. Opportunities and challenges in the further development of the CDots platform and related technologies are discussed.
MULTI-FUNCTIONAL CARBON DOTS: A SYSTEMATIC OVERVIEW Review Article
International Journal of Applied Pharmaceutics, 2021
Carbon dots (CDs) have emerged as a potential material in the multifarious fields of biomedical applications due to their numerous advantageous properties including tunable fluorescence, water solubility, biocompatibility, low toxicity, small size and ease of modification, inexpensive scale-up production, and versatile conjugation with other targeted nanoparticles. Thus, CDs became a preferable choice in various biomedical applications such as nanocarriers for drugs, therapeutic genes, photo sensitizers, unique electronic, fluorescent, photo luminescent, chemiluminescent, and electro chemiluminescent, drug/gene delivery and optoelectronics properties are what gives them potential in sensing and antibacterial molecules. Further, their potentials have also been verified in multifunctional diagnostic platforms, cellular and bacterial bio-imaging, development of nanomedicine, etc. This present review provides a concise insight into the progress and evolution in the field of carbon dots research with respect to synthesis methods and materials available in bio-imaging, theranostic, cancer, gene therapy, diagnostics, etc. Further, our discussion is extended to explore the role of CDs in nanomedicine and nano theranostic, biotherapy which is the future of biomedicine and also serves to discuss the various properties of carbon dots which allow chemotherapy and gene therapy to be safer and more target-specific, resulting in the reduction of side effects experienced by patients and also the overall increase in patient compliance and quality of life and representative studies on their activities against bacteria, fungi, and viruses reviewed and discussed. This study will thus help biomedical researchers in percuss the potential of CDs to overcome various existing technological challenges.
Carbon Quantum Dots Platforms: as nano therapeutic for Biomedical Applications
Quantum dots (QDs) have been widely used as bioimaging agents for fluorescent nanoscopes. However, QD can have toxic side effects because it contains heavy metals. Therefore, many researchers have proposed an alternative material with low toxicity and good biocompatibility called carbon quantum dots (CQD). CQDs have many attractive properties due to their structure such as optical properties, photoluminescence and phosphorescence. These exceptional properties can be used for biomedical applications, especially in the fields of drug delivery, bioimaging, and biosensor. This article provides a comprehensive review of CQDs. The primary focus is on their unique properties and toxicity as they relate to the recently reported field of biomedicine and applications.
Recent advance of carbon dots in bio-related applications
Journal of Physics: Materials, 2020
Carbon dots (CDs) is a kind of carbon nanoparticles with a plentiful of surface functional groups and tunable emission with different excitation wavelength. Broadly speaking, CDs include carbon nanodots, carbon quantum dots, graphene quantum dots, carbonized polymer dots. Due to the unique nature, they are explored for various applications in the bio-related fields such as bioimaging, sensor for ion and (bio)molecules, catalyst, LED and other fields. They are viewed as great alternative tracers to the current fluorescent biomarkers in personalized nanomedicine and surgery operation monitoring. In this review, we summarized the recent progress in the development of CDs, including improvement in fluorescence properties, two-photon fluorescence, and integration with other modalities as theragnostic agents. Specifically, we discussed the preparation of dual-modal imaging agents to improve the accuracy of diagnosis, the combination of imaging and targeting functionality for the effective...
Synthetic routes to theranostic applications of carbon-based quantum dots
ADMET and DMPK
Background and Purpose: Modern technologies are making advanced paths to address emerging issues. The development of carbon dots (CDs) technology at a tiny level has been researched to have made impeccable strides in advancing the modern scientific field, especially in nanomedicine. Experimental Approach: Researchers have gained much attention on CDs of their unique properties in the synthesis, easy surface modifications, excellent optical properties, low toxicity, and water solubility. Doping carbon dots with other elements makes them more convenient for their use in the medical sector. Key Results: The manuscript provides a detailed discussion of the two main methods, including the hydrothermal pathway. CDs are synthesized bottom-up by building up molecules at the atomic scale and top-down by transforming large carbon particles into nanoscale dimensions. Conclusion: The present article discussed the role, importance, and recent advancements in the synthesis of CDs, by using variou...