Overview of panels of proteins and their physiological pathways predicting the different malaria clusters (original) (raw)

2014

Abstract

<p>Proteins with differential profiles between the malaria groups were classified into physiological pathways. This included proteins identified common to all malaria groups (blue bars), common to both defined severe malaria syndromes (purple bars), proteins with levels elevated in SMA (light green bars), proteins with levels elevated in CM (light orange bars) and proteins specific to CM (dark orange bars). For each panel, columns were stacked by number of proteins identified in each category. Grey dotted connectors represent either a regulation link or a common protein component between to physiological pathways. UM: uncomplicated malaria; SMA: severe malaria anemia; CM: cerebral malaria. Proteins are represented by their gene names (Refer to <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1004038#ppat-1004038-t002" target="_blank">Table 2</a>, Fig. S3 and Table S2 in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1004038#ppat.1004038.s001" target="_blank">Text S1</a> for full names).</p

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