483: Correlates of urinary arsenic metabolites in women of childbearing age in the national health and nutrition examination survey (NHANES) 2000-2010 (original) (raw)

2015, American Journal of Obstetrics and Gynecology

OBJECTIVE: To evaluate the associations between urinary arsenic metabolites with pregnancy and select demographic, biometric, dietary, hormonal factors. STUDY DESIGN: This cross-section study analyzed 195 pregnant (PG) and 1178 not pregnant (not PG) women <55 years with urinary arsenic results from NHANES 2000-2010. We analyzed 8 Arsenic values and also mean Arsenic value of URXUAS-Urinary total Arsenic (Âmg/L) , URXUAB-Urinary Arsenobetaine (Âmg/L) and URXUDMA-Urinary Dimethylarsonic acid (Âmg/L). The database included all dietary intakes (total energy calories, lipids, sugars, protein, fibers), vitamin intakes (A,B1, B12, B6, folate, niacin, C, E, K), trace metals intakes (calcium, phosphorus, magnesium, zinc, iron, selenium, copper, potassium), alcohol, caffeine, and theobromine intakes. HOMA IR Insulin resistance was calculated. We analyzed Arsenic quartiles using Chi-square, Fisher's Exact tests, Kruskal-Wallis tests, Jonckheere-Terpstra tests of trend (JT p¼). Logistic regression of the highest Arsenic quartile was performed with PG/noPG using the following covariates (urine creatinine, ethnicity, total Kcal of energy, total fats, age, smoking, waist circumference, arm circumference, BMI, Iron). RESULTS: Pregnant subjects had significantly lower values for most of the urinary arsenic metabolites. Sub scapular skin-fold; dietary intake of cholesterol, vitamin C, selenium, caffeine, and vitamin K were statistically significantly different with significant JT p values for linear trend. Logistic regression showed association between decreased arsenic levels with pregnancy only when creatinine was a covariate (OR¼0.651,95%CI:0.434, 0.975), the most significant associations were with non-Hispanic Blacks (OR¼1.532,95% CI:1.077,2.178) and non-Hispanic whites (OR¼0.685, 95% CI:0.498,0.943). CONCLUSION: There are possible correlations between pregnancy and ethnicity with arsenic exposure.