Saccharothrix algeriensis, a new antibiotic producer: investigations on its secondary metabolism (original) (raw)
The constant growth of the antibiotic world market leads to study rare actinomycete. Therefore, the bacterium Saccharothrix algeriensis which products new antibiotics of dithiolopyrrolone class is studied in liquid culture. The aim of this work is to better apprehend the mechanisms which govern the bacterial growth as well as the dithiolopyrrolones synthesis and to capitalize this knowledge in a general reactional scheme of the metabolism. The growth of Saccharothrix algeriensis was performed in a batch reactor, on a semisynthetic medium. The growth, the thiolutine (the main dithiolopyrrolone) and the carbon dioxide production and the substrates consumption were monitored. The influence of the substrate concentration on growth and on the production of dithiolopyrrolones was evaluated. It seems that diauxic growth occurs on amino acids then on glucose. The thiolutine synthesis would be induced by carbon substrates exhaustion and by ammonium ions deficiency. Glucose seems to exert a catabolite repression on the secondary metabolic activities of the cell.
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