European Journal of Medicinal Chemistry (original) (raw)

Schiff base ligands, recognized as adaptable and effective agents in various applications, especially in medicinal chemistry, were explored for their coordination with organotin compounds. This study investigates the biological activity of novel organotin compounds synthesized from diorganotin(IV) halides and a specific Schiff base derived from salicylaldehyde and adenine. The antibacterial and antifungal properties of these compounds were evaluated, with significant findings indicating their potential as effective antimicrobial agents. Results show that the biological activity is influenced by the structure of the organotin ligands, with some complexes demonstrating considerable efficacy against several Gram-positive and Gram-negative bacteria as well as fungi.