In-vitro Cyclooxygenase Inhibitory, Antioxidant and Antimicrobial Activities of Phytochemicals Isolated from Crassula arborescens (Mill.)Willd (original) (raw)

2016

Abstract

Summary. Seven phenolic compounds, one sterol and mixture of triterpenes were isolated from the Crassula arborescens extract. The isolated compounds were identified on the basis of Mass and NMR spectroscopic methods and identified as, vanillic acid (1), methyl gallate (2), p -hydroxy benzoic acid (3), procatechuic acid (4), gallic acid (5), Isorhamentin (6), quercetin (7), α , β amyrin as a mixture (8a, 8b), and β -sitosterol (9). In-vitro antioxidant, antimicrobial and cyclooxygenase inhibitory activities of the isolated compounds were evaluated. The antioxidant activity using DPPH radical scavenging assay showed that quercetin and gallic acid were the most potent antioxidant with 93.6%, 92.2 % inhibition of DPPH respectively. Antimicrobial activity against some pathogenic microorganisms clear that vanillic acid, procatechuic acid and isorhamentin showed a potent antimicrobial activity with MIC range from 12.5 to 100 µg/ml against Enterococcus faecalis , Sarcina lutea , Mycobacteri...

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