Mesenteric Castleman's disease: case report (original) (raw)
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Mesenteric Castleman's Disease: Case Report and Literature Review
Asian Journal of Surgery, 2010
A 41-year-old man was discovered to have a pelvic mass during investigation for hypertension 2 years ago. Otherwise, he was asymptomatic, and abdominal magnetic resonance imaging revealed a highly vascular solid mass superior to the urinary bladder. A 131 I-meta-iodobenzylguanidine whole body scan was reported as normal, which ruled out the possibility of extra-adrenal pheochromocytoma. No definitive preoperative diagnosis could be established. Surgical resection of the tumour revealed mesenteric Castleman's disease, hyaline vascular type. Such a diagnosis should be considered for any abdominal vascular mass. [Asian J Surg 2010;33(3):150-3]
Castleman’s disease of the mesocolon: a rare case report
Biomedical Research and Therapy, 2014
Castleman's disease is a rare form of localized lymph node hyperplasia of unknown etiology. The sub-types are; hyaline vascular, plasma cell and mixed variant. Clinical subtypes are localized (unicentric) and multicentric. It is reported in all age groups regardless of gender. Hyaline vascular type, accounts for 90% of all cases, often develops in the neck, mediastinum and pulmonary hilum. Its occurrence in the peritoneal cavity is very rare. We present a case in mesocolon of hyaline type in a 39 year female.
Mesenteric Castleman disease: sonographic diagnosis
Journal of clinical ultrasound, 1992
Castleman disease,' also known as giant lymph node hyperplasia,' lymphoid h a m a r t~r n a ,~ angiomatous lymphoid hyperplasia,* and angiofollicular mediastinal lymph node hyperpla~ia,~ is a relatively rare, benign disorder. In 70% of cases this idiopathic tumor occurs in the mediastinurn.'s5 The neck,6 retr~peritoneum,~,~ pancreas,' pelvic cavity," and axillary and inguinal lymph nodes" are uncommon sites of involvement. Mesenteric Castleman tumors are considered very rare. To our knowledge, only 12 cases have been reported.l1,l2 We report the sono-From the
Castleman Disease: A Wide Spectrum of Thoracic Manifestations
Medical research archives, 2022
Castleman’s disease is a benign lymphoproliferative disorder affecting both lymph nodes and extranodal loci. Castleman’s disease can occur in practically any part of the body, but it occurs mainly in the thorax (~70%) followed by the abdomen and pelvis, neck and axilla. Clinically, Castleman’s disease can be classified into a unicentric or multicentric form, depending on the number of lymph nodes involved, and histologically into a hyaline vascular variant, plasma cell, mixed cellular or plasmablastic variant. In this mini-review we briefly report and focus on all clinical thoracic manifestations of Castleman’s disease resuming for each of them the possible strategy of treatment.
Radiographics, 2016
Castleman disease is a complex lymphoproliferative disease pathologically divided into two subtypes, the hyaline vascular variant (HVV) and the plasma cell variant (PCV). The HVV is the most common, is thought to represent a benign neoplasm of lymph node stromal cells, and is treated with surgical resection. It is most commonly found in the mediastinum, where it classically appears as a unicentric, avidly enhancing mass at computed tomography (CT) and magnetic resonance imaging. This appearance can mimic other avidly enhancing mediastinal masses, and location, clinical history, laboratory data, and nuclear medicine single photon emission CT (SPECT) and positron emission tomography (PET) studies can help narrow the differential diagnosis. Multicentric Castleman disease (MCD), which in the majority of cases is composed of the PCV, is an aggressive lymphoproliferative disorder associated with human herpesvirus infection, interleukin 6 dysregulation, and other systemic disorders. While it can be difficult to differentiate MCD from lymphoma, the presence of avidly enhancing lymph nodes can suggest the diagnosis. The purpose of this article is to review the clinical, immunologic, and pathologic findings associated with both unicentric Castleman disease and MCD and discuss how the imaging findings correlate with the pathophysiology of the disease.
Imaging features of atypical thoracic Castleman disease
Clinical Imaging, 2004
The imaging features of 16 cases of pathologically proven atypical thoracic Castleman disease (CD) were retrospectively reviewed. Thirteen out of 16 tumors originated from atypical locations, including eight from the pleura and one each from the axilla, supraclavicular fossa, intercostal space, pericardium, and lung. Six out of 16 tumors revealed atypical enhancement, including poor CT enhancement in three tumors, targetlike CT enhancement in two tumors, and concentric MR enhancement pattern in one tumor. These atypical enhancement patterns were histopathologically corresponded to various degrees of degeneration, necrosis, and fibrosis. D
Isolated Intrapulmonary Castleman’s Disease: A Case Report, Review of the Literature
Annals of Thoracic and Cardiovascular Surgery, 2014
Castleman's disease (CD), also known as angiofollicular lymph node hyperplasia, is an uncommon, lymphoproliferative disorder of unknown etiology, mostly involving the mediastinum. Parenchymal lung involvement of the disease is extremely rare. Intrapulmonary CD has been reported in seven cases in the English literature. We describe an asymptomatic 28-year-old woman with lesion in the chest X-ray. Computed tomography (CT) of the chest confirmed a 5.5 × 5 cm well-defined, lobulated mass in the hilum of the right upper lobe. She underwent surgical resection for diagnosis and treatment. Pathologic examination showed hyaline vascular type (Castleman's disease) lymph node hyperplasia. CD rarely arises from the intrapulmonary lymph nodes. In these patients, preoperative diagnosis is difficult and invasive attempts may be required.
Castleman’s Disease: Due to a Rare Intraabdominal Location
Forbes Journal of Medicine, 2021
Castleman disease (CD) is a rare benign disease with unknown etiology. It is also called angiofollicular lymph node hyperplasia, giant lymph node hyperplasia, lymph node hamartoma, benign giant lymphoma. Histologically, it is classified as hyaline vascular and plasma cell variant, but rarely features of two types can coexist. Most of the cases with unisentric disease are hyaline vascular and most of the cases with multicentric disease are in plasma cell histological type. Although it is frequently located in thorax, it can be found throughout the body. Salivary glands, lungs, pancreas, larynx, parotid gland, meninges, and even limb muscles can be affected as extralymphatic spread. Since it is localized in the middle and anterior mediastinum in the thorax, it should be differentiated from mediastinal autoimmune and neoplastic diseases. In this case report, we aimed to present the radiological findings of a CD case with a rare intraabdominal location.
Castleman's Disease: An Intrapulmonary Form with Intrafissural Development
The Scientific World JOURNAL, 2009
Castleman's disease (CD) is an uncommon, mainly benign, lymphoproliferative disorder of unknown etiology, mostly involving the mediastinum. Parenchymal lung involvement of the disease is exceedingly rare. We describe a case of CD in a 23-year-old woman with a 4-year history of recurring dyspnea and nonproductive cough, whose chest X-ray showed an abnormal shadow of the right hilum. Chest computed tomography confirmed the presence of a tissue-density mass of the right lower lobe, demonstrating poor contrast enhancement, associated with multiple laterotracheal and mediastinal lymphadenopathies. The patient underwent curative surgery, revealing a right hilar compressive mass, with an intrafissural development between the superior and middle lobes. Pneumonectomy was performed due to profuse bleeding. This case of CD is particular because of its unusual intrapulmonary location and its intrafissural development. Poor contrast enhancement is atypical in CD.